Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Male-specific lethal 1 homolog (Msl1)

Recombinant Mouse Male-specific lethal 1 homolog (Msl1)

  • 中文名称：
    小鼠Msl1重组蛋白
  • 货号：
    CSB-YP747470MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Msl1重组蛋白
  • 货号：
    CSB-EP747470MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Msl1重组蛋白
  • 货号：
    CSB-EP747470MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Msl1重组蛋白
  • 货号：
    CSB-BP747470MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Msl1重组蛋白
  • 货号：
    CSB-MP747470MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Msl1
  • Uniprot No.：
  • 别名：
    Msl1; Msl1l1; Male-specific lethal 1 homolog; MSL-1; Hampin; Male-specific lethal 1-like 1; MSL1-like 1; Male-specific lethal-1 homolog 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-616
  • 氨基酸序列
    MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDESGA AEAHFLPRHR KLKEPGPPLA SSQGGSPSPS PAGCGGGKGR GLLLPAGAAP GQQEESWGGS VPLPCPPPAT KQAGIGGEPV AAGAGCSPRP KYQAVLPIQT GSIVVAAAKE PTPWAGDKGG AAPPAATASD PAGPPPLPLP GPPPLAPTAT AGTLAASEGR WKSIRKSPLG GGGGSGASSQ AACLKQILLL QLDLIEQQQQ QLQAKEKEIE ELKSERDTLL ARIERMERRM QLVKRDNEKE RHKLLQGYEP EEREEAELSE KIKLERQPEL CETSQALPSK PFSCGRSGKG HKRKTPFGNT ERKTPVKKLA PEFSKVKTKT PKHSPIKEEP CGSISETVCK RELRSQETPE KPRSSVDTPP RLSTPQKGPS THPKEKAFSS EMEDLPYLST TEMYLCRWHQ PPPSPLPLRE SSPKKEETVA RCLMPSSVAG ETSVLAVPSW RDHSVEPLRD PNPSDILENL DDSVFSKRHA KLELDEKRRK RWDIQRIREQ RILQRLQLRM YKKKGIQESE PEVTSFFPEP DDVESLLITP FLPVVAFGRP LPKLAPQNFE LPWLDERSRC RLEIQKKHTP HRTCRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys-16' (H4K16ac).
  • 基因功能参考文献：
    1. Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). PMID: 28609438
    2. Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1. PMID: 21217699
    3. hampin may be linked to diverse regulatory processes in the nucleus PMID: 17335777
    4. Describes the primary structure of the protein hampin, which shares about 26% sequence identity with the Drosophila MSL1 protein. In mouse, at least five splice isoforms exist, two of which have restricted tissue specificity (testes). PMID: 16119455
  • 亚细胞定位：
    Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus. Nucleus speckle.; [Isoform 3]: Nucleus. Nucleus, nucleoplasm.; [Isoform 4]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus, nucleoplasm.
  • 蛋白家族：
    Msl-1 family
  • 组织特异性：
    Isoform 3 and isoform 5 are testis-specific. Isoform 1 and isoform 4 are ubiquitously expressed. Isoform 2 is expressed at low levels in the testis and brain.
  • 数据库链接：

    KEGG: mmu:74026

    STRING: 10090.ENSMUSP00000042792

    UniGene: Mm.258352