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  4. Recombinant Mouse Lysozyme C-2 (Lyz2)

Recombinant Mouse Lysozyme C-2 (Lyz2)

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  • 中文名称：
    小鼠Lyz2重组蛋白
  • 货号：
    CSB-EP357518MO
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Lyz2
  • Uniprot No.：
  • 别名：
    Lyz2; Lyz; LyzsLysozyme C-2; EC 3.2.1.17; 1,4-beta-N-acetylmuramidase C; Lysozyme C type M
  • 种属：
    Mus musculus(Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    19.8 kDa
  • 表达区域：
    19-148aa
  • 氨基酸序列
    KVYERCEFARTLKRNGMAGYYGVSLADWVCLAQHESNYNTRATNYNRGDQSTDYGIFQINSRYWCNDGKTPRAVNACGINCSALLQDDITAAIQCAKRVVRDPQGIRAWVAWRAHCQNRDLSQYIRNCGV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.
  • 基因功能参考文献：
    1. Results show that lysozyme (LYSO) - induced Staphylococcus aureus bacteriostasis increased with increasing concentrations of baicalin, and that baicalin binding to LYSO synergistically increased the antibacterial activity of LYSO. PMID: 28184027
    2. Data show that receptor-interacting serine-threonine kinase 3 (RIPK3) deletion prevents inflammatory phenotypes in CreLysM (lysozyme M) Casp8fl/fl (caspase 8) mice. PMID: 26471282
    3. Depletion of LysM(+) cells attenuated ATII-induced blood pressure increase. PMID: 21875910
    4. ApoE and lysozyme M have roles in monocyte and neutrophil trafficking in atherosclerosis in a mouse model PMID: 18508059
    5. P-tau was found in medial entorhinal cortex of Naglu(-/-) mice, in the same neurons as lysozyme PMID: 19416848

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glycosyl hydrolase 22 family
  • 组织特异性：
    Expressed weakly in myeloblasts, moderately in immature macrophages, and strongly in both mature macrophages and macrophage-rich tissues.
  • 数据库链接：

    KEGG: mmu:17105

    STRING: 10090.ENSMUSP00000089801

    UniGene: Mm.45436