Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Liver carboxylesterase 1 (Ces1)

Recombinant Mouse Liver carboxylesterase 1 (Ces1)

  • 中文名称：
    Recombinant Mouse Liver carboxylesterase 1(Ces1),Yeast
  • 货号：
    CSB-YP848671MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Liver carboxylesterase 1(Ces1),Yeast
  • 货号：
    CSB-EP848671MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Liver carboxylesterase 1(Ces1),Yeast
  • 货号：
    CSB-BP848671MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Liver carboxylesterase 1(Ces1),Yeast
  • 货号：
    CSB-MP848671MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ces1
  • Uniprot No.：
  • 别名：
    Ces1; Ces1gLiver carboxylesterase 1; EC 3.1.1.1; Acyl-coenzyme A:cholesterol acyltransferase; Carboxylesterase 1G; ES-x
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-565
  • 氨基酸序列
    HP SLPPVVHTVH GKVLGKYVTL EGFSQPVAVF LGVPFAKPPL GSLRFAPPEP AEPWSFVKHT TSYPPLCYQN PEAALRLAEL FTNQRKIIPH KFSEDCLYLN IYTPADLTQN SRLPVMVWIH GGGLVIDGAS TYDGVPLAVH ENVVVVVIQY RLGIWGFFST EDEHSRGNWG HLDQVAALHW VQDNIANFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAIAQSSVI FNPCLFGRAA RPLAKKIAAL AGCKTTTSAA MVHCLRQKTE DELLEVSLKM KFGTVDFLGD PRESYPFLPT VIDGVLLPKA PEEILAEKSF NTVPYMVGIN KHEFGWIIPM FLDFPLSERK LDQKTAASIL WQAYPILNIS EKLIPAAIEK YLGGTEDPAT MTDLFLDLIG DIMFGVPSVI VSRSHRDAGA PTYMYEYQYR PSFVSDDRPQ ELLGDHADEL FSVWGAPFLK EGASEEEINL SKMVMKFWAN FARNGNPNGE GLPHWPEYDQ KEGYLQIGVP AQAAHRLKDK EVDFWTELRA KETAERSSHR EHVEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
  • 基因功能参考文献：
    1. Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury. PMID: 27881673
    2. Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin sensitivity. PMID: 26976727
    3. Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses. PMID: 24194565
    4. Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR-controlled lipid homeostasis PMID: 24038130
    5. Ces1/Es-x participates in the regulation of chylomicron assembly and secretion. PMID: 23145182
    6. These studies support a role for Ces1/Es-x in the partitioning of regulatory fatty acids and concomitant control of hepatic lipid biosynthesis, secretion, and deposition. PMID: 22806626
    7. Es-x limits hepatic triacylglycerol accumulation by promoting beta-oxidation. PMID: 19651238

    显示更多

    收起更多

  • 亚细胞定位：
    Endoplasmic reticulum lumen. Cytoplasm. Lipid droplet.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 组织特异性：
    Detected in kidney, liver and lung.
  • 数据库链接：

    KEGG: mmu:12623

    UniGene: Mm.22720