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  4. Recombinant Mouse Leukocyte elastase inhibitor A (Serpinb1a)

Recombinant Mouse Leukocyte elastase inhibitor A (Serpinb1a)

  • 中文名称：
    小鼠Serpinb1a重组蛋白
  • 货号：
    CSB-YP866658MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Serpinb1a重组蛋白
  • 货号：
    CSB-EP866658MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Serpinb1a重组蛋白
  • 货号：
    CSB-EP866658MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Serpinb1a重组蛋白
  • 货号：
    CSB-BP866658MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Serpinb1a重组蛋白
  • 货号：
    CSB-MP866658MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Serpinb1a
  • Uniprot No.：
  • 别名：
    Serpinb1a; Serpinb1; Leukocyte elastase inhibitor A; Serine protease inhibitor EIA; Serpin B1a
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-379
  • 氨基酸序列
    MEQLSSANTL FALELFQTLN ESSPTGNIFF SPFSISSALA MVILGAKGST AAQLSKTFHF DSVEDIHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF LPEYLASTQK MYGADLAPVD FLHASEDARK EINQWVKGQT EGKIPELLSV GVVDSMTKLV LVNAIYFKGM WEEKFMTEDT TDAPFRLSKK DTKTVKMMYQ KKKFPFGYIS DLKCKVLEMP YQGGELSMVI LLPKDIEDES TGLKKIEKQI TLEKLLEWTK RENLEFIDVH VKLPRFKIEE SYTLNSNLGR LGVQDLFSSS KADLSGMSGS RDLFISKIVH KSFVEVNEEG TEAAAATGGI ATFCMLLPEE EFTVDHPFIF FIRHNPTSNV LFLGRVCSP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of granzyme H. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. In addition, promotes the proliferation of beta-cells when secreted.
  • 基因功能参考文献：
    1. SerpinB1 is a conserved endogenous secretory protein that promotes proliferation of beta cells. PMID: 26701651
    2. our findings reveal a novel function of serpinB1 in limiting untoward expansion of lymphocytes with a Th17 phenotype. PMID: 24249741
    3. SerpinB1 is critical for maintaining polymorphonuclear neutrophils survival by antagonizing intracellular cathepsin G activity. PMID: 23532733
  • 亚细胞定位：
    Secreted. Cytoplasm. Cytolytic granule. Early endosome.
  • 蛋白家族：
    Serpin family, Ov-serpin subfamily
  • 组织特异性：
    Ubiquitous with higher expression in pancreas, spleen and bone marrow.
  • 数据库链接：

    KEGG: mmu:66222

    STRING: 10090.ENSMUSP00000075690

    UniGene: Mm.20144