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  4. Recombinant Mouse Lanosterol synthase (Lss)

Recombinant Mouse Lanosterol synthase (Lss)

  • 货号：
    CSB-YP804370MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804370MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804370MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804370MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804370MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lss
  • Uniprot No.：
  • 别名：
    LssLanosterol synthase; EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-733
  • 氨基酸序列
    TEGTCLRRR GGPYKTEPAT DLTRWRLQNE LGRQRWTYYQ AEDDPGREQT GLEAHSLGLD TRSYFTDLPK AQTAHEGALN GVTFYAKLQA EDGHWAGDYG GPLFLLPGLL ITCHISHISL PAGYREEMVR YLRSVQLPDG GWGLHIEDKS TVFGTALNYV ALRILGIGPD DPDLVRARNV LHKKGGAVAI PSWGKFWLAV LNVYSWEGLN TLFPEMWLFP EWVPAHPSTL WCHCRQVYLP MSYCYATRLS ASEDPLVQSL RQELYVQDYA SIDWPAQRNN VSPDEMYTPH SWLLHVVYGL LNLYERFHST SLRKWAVQML YEHIAADDCF TKCISIGPIS KTINMLVRWS VDGPSSPAFQ EHVSRIKDYL WLGLDGMKMQ GTNGSQIWDT SFAIQALLEA GAHHRPEFLP CLQKAHEFLR LSQVPENCPD YQKYYRHMRK GGFSFSTLDC GWIVADCTAE GLKAVLLLQN QCPSITEHIP RERLCDAVDV LLSLRNADGG FATYEKKRGG YLLELLNPSE VFGDIMIDYT YVECTSAVMQ ALKHFHEHFP DYRAAEVRET LNQGLDFCRR KQRADGSWEG SWGVCFTYGT WFGLEAFACM GHTYQDGAAC AEVAQACNFL LSQQMADGGW GEDFESCEQR RYVQSARSQV HSTCWALMGL MAVRHPDITA QERGIRCLLG KQLPNGDWPQ ENISGVFNKS CAISYTSYRN IFPIWALGRF SNLYPDNTLA GHI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
  • 基因功能参考文献：
    1. liver-specific ablation of squalene synthase inhibits hepatic cholesterol biosynthesis and induces hypolipidemia without increasing significant mortality. PMID: 25755092
    2. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. PMID: 19119143
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    Terpene cyclase/mutase family
  • 数据库链接：

    KEGG: mmu:16987

    STRING: 10090.ENSMUSP00000046856

    UniGene: Mm.55075