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  4. Recombinant Mouse Laccase domain-containing protein 1 (Lacc1)

Recombinant Mouse Laccase domain-containing protein 1 (Lacc1)

  • 货号：
    CSB-YP804436MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804436MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804436MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804436MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804436MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lacc1
  • Uniprot No.：
  • 别名：
    Lacc1Laccase domain-containing protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-430
  • 氨基酸序列
    MAEAVLIDLS GLQLNAQKNC HETLLETLDG IHYHHAPKAK FLCIICCRNA SKEKDGEYGL CELEAGNGFS RLAGKFETVS HPCLAASLYT IKQKIDEENL SCIKVIVPEH RKLLMKAYVG QLFTEVYEFE FEDLQGAWRD SLLKPSTGIN VTTTQELEDI QHEIETYLRS LPALKGDLTI VTSPLIPDNF LHGFTTRTGG ISSVPTLSSL NLFSSSKRRD PKVVVQENVR RLANAAGFNA EKFYRIKTDH ASEVWVMGKK EPESYDGIVT NQRGVTITAL GADCIPIVFA DPVKKACGVA HSGWKGTLLG VAMATVNAMI AEYGCDVEDI IVVLGPSVGS CCFTLPKESA VSFHSLHPSC VRHFDSPRPY VDIRKATRIL LERGGILPQN IQDQKEDLDL CTSCHPEKFF SHVRDGLNFG TQIGFISLRE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity. Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages. Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface. The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity. Participates in pattern recognition receptor-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance. Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR). Does not show laccase activity.
  • 基因功能参考文献：
    1. this study shows that Lacc1 is a central regulator of the metabolic function and bioenergetic state of macrophages that is under evolutionary selection and determines the risk of inflammatory and infectious disease PMID: 27478939
  • 亚细胞定位：
    Cytoplasm. Nucleus. Endoplasmic reticulum. Peroxisome.
  • 蛋白家族：
    LACC1 family
  • 组织特异性：
    Predominantly expressed in myeloid cells. Highly expressed in primary macrophages and dendritic cells sorted from the peritoneum or spleen, respectively (at protein level).
  • 数据库链接：

    KEGG: mmu:210808

    STRING: 10090.ENSMUSP00000059173

    UniGene: Mm.89278