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  4. Recombinant Mouse LIM homeobox transcription factor 1-alpha (Lmx1a)

Recombinant Mouse LIM homeobox transcription factor 1-alpha (Lmx1a)

  • 中文名称：
    小鼠Lmx1a重组蛋白
  • 货号：
    CSB-YP872874MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lmx1a重组蛋白
  • 货号：
    CSB-EP872874MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lmx1a重组蛋白
  • 货号：
    CSB-EP872874MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lmx1a重组蛋白
  • 货号：
    CSB-BP872874MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lmx1a重组蛋白
  • 货号：
    CSB-MP872874MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lmx1a
  • Uniprot No.：
  • 别名：
    Lmx1a; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LMX-1.1; LIM/homeobox protein LMX1A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-382
  • 氨基酸序列
    MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGASEDGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
  • 基因功能参考文献：
    1. Data show that sustained expression of Lmx1a and Lmx1b is required for the survival of adult midbrain dopaminergic neurons. PMID: 27407143
    2. Lmx1a and Lmx1b regulate Plxnc1 expression.Lmx1a is required for the topographical organization of dopaminergic innervation in the striatum. PMID: 29038581
    3. Lmx1a is expressed in enterochromaffin cells and functions downstream of Nkx2.2. PMID: 27287799
    4. This study showed that spontaneous Lmx1a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. PMID: 25907855
    5. The data of this study that Oc-1 interacts with Lmx1a to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1-Lmx1a pathway. PMID: 25747864
    6. Lmx1a signaling in mouse embryonic stem cells contributes to a molecular cascade establishing neuronal specification. PMID: 24194952
    7. our data demonstrate that key midbrain dopamine regulators (Nurr1, Pitx3, and Lmx1a) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons PMID: 24172139
    8. The data of this study suggested that aberrant anlage patterning and granule cell development lead to Purkinje cell ectopia, which ultimately causes abnormal cerebellar architecture in dreher. PMID: 23160833
    9. dopamine transporter is a direct target of Lmx1a and emphasizes a novel role of Lmx1a as one of regulators of mature midbrain dopaminergic neurotransmitter phenotypes PMID: 22564125
    10. Lmx1a mutant (dr/dr) embryos demonstrate a clear decrease in expression of the genes Grb10 and Rgs4. PMID: 23106268
    11. The characterization of two new Lmx1a alleles highlights the critical role of this gene in the development of the cochlea and vestibular system. PMID: 23226461
    12. Data conclude that Lmx1a is a useful marker for the extraction of progenitors of GABAergic or dopaminergic neurons. PMID: 22495882
    13. The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
    14. This study demonstrated that Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of mDA progenitors, including their floor plate-like properties. PMID: 21880902
    15. data establish that Lmx1b influences the differentiation of multiple neuronal subtypes in the ventral midbrain, whereas Lmx1a appears to be exclusively devoted to the differentiation of the dopamine neuron lineage PMID: 21752929
    16. Generation of knockout mice expressing a GFP-reporter under the control of the Lmx1a locus. PMID: 21440093
    17. In the developing cerebellum, Lmx1a is expressed in the roof plate, where it is required to segregate the roof plate lineage from neuronal rhombic lip derivatives. PMID: 20498066
    18. obtained evidence that Lmx1a and Lmx1b cooperate with Foxa2 to specify mesDA neuron identity by gain-of-function approaches using transgenic mice PMID: 20035737
    19. Lmx1a/Lmx1b null mutant mice fail to generate a hindbrain roof plate. Both genes act in concert to direct normal hindbrain formation. PMID: 19741143
    20. Lmx1a is expressed in the dorsal midline (roof plate) of the neural tube, the cortical hem, the otic vesicles, the developing cerebellum and the notochord of developing mice PMID: 12351192
    21. New spontaneous Lmx1a mutations and analysis of six additional suggest that all reported alleles mutations are null mutations. PMID: 17019651
    22. Otx2 determines anterior identity that confers neurogenic activity to floor plate cells and specifies a mesencephalon-dopaminergic fate, at least in part through the induction of Lmx1a. PMID: 17670789
    23. Expression of Lmx1a and Isl1 begins in the otocyst stage, with Lmx1a exclusively in the non-sensory and Isl1 in the prosensory epithelia. PMID: 18942141
    24. Lmx1a expression restricts and sharpens Sox2 expression, thereby defining non-sensory and sensory epithelium. PMID: 18985389
    25. results suggest that Lmx1a may be involved in postnatal development as well as in maintenance of some aspects of normal brain function PMID: 19111912
    26. forced expression of Lmx1a, a transcription factor functioning as a determinant of mesDA neurons during embryogenesis, effectively can promote the generation of mesDA neurons from mouse and human embryonic stem cells. PMID: 19383789
    27. In an Lmx1a functional null mutant, dreher, the inner ears lack a non-sensory structure, the endolymphatic duct, and the membranous labyrinth is poorly developed. These phenotypes are consistent with Lmx1a's role as a selector gene. PMID: 19540218
    28. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development PMID: 19607821

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  • 相关疾病：
    Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:110648

    STRING: 10090.ENSMUSP00000028003

    UniGene: Mm.330081