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  4. Recombinant Mouse LDLR chaperone MESD (Mesdc2)

Recombinant Mouse LDLR chaperone MESD (Mesdc2)

  • 中文名称：
    小鼠Mesd重组蛋白
  • 货号：
    CSB-YP880641MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mesd重组蛋白
  • 货号：
    CSB-EP880641MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mesd重组蛋白
  • 货号：
    CSB-EP880641MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mesd重组蛋白
  • 货号：
    CSB-BP880641MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mesd重组蛋白
  • 货号：
    CSB-MP880641MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mesd
  • Uniprot No.：
  • 别名：
    Mesd; Mesdc2LRP chaperone MESD; LDLR chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-224
  • 氨基酸序列
    A DTPGEATPPP RKKKDIRDYN DADMARLLEQ WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK KGKTLMMFVT VSGNPTEKET EEITSLWQGS LFNANYDVQR FIVGSDRAIF MLRDGSYAWE IKDFLVSQDR CAEVTLEGQM YPGKGGGSKE KNKTKPEKAK KKEGDPKPRA SKEDNRAGSR REDL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
  • 基因功能参考文献：
    1. Mescd2 binds to Lrp4 and regulates Lrp4 surface expression in myotubes. PMID: 24140340
    2. Mesd C-terminal region constitutes the major LRP5/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer PMID: 23469146
    3. The region 45-184 of MESD is essential and sufficient to act as a molecular chaperone for the low-density lipoprotein receptor (LDLR) family. PMID: 21397185
    4. We show that MESD contains a central folded domain flanked by unstructured regions required to facilitate maturation of LRP6. Enforced expression of human MESD promotes the secretion of soluble minireceptors derived from LRP6. PMID: 17488095
    5. Functional analyses of the Lrp6 rs mutant showed decreased targeting to plasma membrane because of reduced interaction with Mesoderm development (Mesd), a chaperone for Lrp6, leading to impaired Wnt/beta-catenin signaling PMID: 18505367
    6. Secondary structure prediction using chemical shift data indicates that MESD(12-155) contains four a-helices and five b-sheets. PMID: 19636811
    7. Mesd not only blocks binding of Dickkopf (DKK)-1 and sclerostin proteins to low-density lipoprotein receptor-related protein (LRP)5 and LRP6 but also inhibits Wnt/beta-catenin signaling in LRP5- or LRP6- expressing cancer cells. PMID: 20446724
    8. Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6. PMID: 16263759

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  • 亚细胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    MESD family
  • 组织特异性：
    Expressed in many tissues, but not in skeletal muscles. In the retina expressed in retinal ganglion cells, inner and outer plexiform layers, photoreceptor inner and outer segments and retinal pigment epithelium (at protein level).
  • 数据库链接：

    KEGG: mmu:67943

    STRING: 10090.ENSMUSP00000091768

    UniGene: Mm.117365