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  4. Recombinant Mouse Krueppel-like factor 15 (Klf15)

Recombinant Mouse Krueppel-like factor 15 (Klf15)

  • 中文名称：
    小鼠Klf15重组蛋白
  • 货号：
    CSB-YP863639MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klf15重组蛋白
  • 货号：
    CSB-EP863639MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klf15重组蛋白
  • 货号：
    CSB-EP863639MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klf15重组蛋白
  • 货号：
    CSB-BP863639MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klf15重组蛋白
  • 货号：
    CSB-MP863639MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klf15
  • Uniprot No.：
  • 别名：
    Klf15; CklfKrueppel-like factor 15; Cardiovascular Krueppel-like factor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-415
  • 氨基酸序列
    MVDHLLPVDE TFSSPKCSVG YLGDRLASRQ PYHMLPSPIS EDDSDVSSPC SCASPDSQAF CSCYSAGPGP EAQGSILDFL LSRATLGSGG GSGGIGDSSG PVTWGSWRRA SVPVKEEHFC FPEFLSGDTD DVSRPFQPTL EEIEEFLEEN MEAEVKEAPE NGSRDLETCS QLSAGSHRSH LHPESAGRER CTPPPGGTSG GGAQSAGEGP AHDGPVPVLL QIQPVAVKQE AGTGPASPGQ APESVKVAQL LVNIQGQTFA LLPQVVPSSN LNLPSKFVRI APVPIAAKPI GSGSLGPGPA GLLVGQKFPK NPAAELLKMH KCTFPGCSKM YTKSSHLKAH LRRHTGEKPF ACTWPGCGWR FSRSDELSRH RRSHSGVKPY QCPVCEKKFA RSDHLSKHIK VHRFPRSSRA VRAIN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. Involved in podocyte differentiation.
  • 基因功能参考文献：
    1. low expression of KLF15 was associated with chronic podocyte injury. PMID: 29901095
    2. study highlights the GC-KLF15-BCAA pathway as a contributor to SMA pathogenesis and provides several treatment avenues to alleviate peripheral manifestations of the disease. PMID: 29735415
    3. Adipose-specific Klf15-deficient mice exhibit increased lipolysis. PMID: 29241541
    4. Data discovered that deletion of Per3 promotes adipogenesis in vivo by a clock output pathway in which PER3 and BMAL1 directly regulate Klf15 expression. PMID: 29186676
    5. Mouse disease model data provide strong evidence for the role of KLF15 in kidney fibrosis through the regulation of the Wnt/beta-catenin pathway in myofibroblasts. PMID: 28651950
    6. observations establish KLF15 as a critical mediator of the cardiac adaptive response to fasting through its regulation of myocardial lipid utilization PMID: 29408889
    7. The expression of Klf15 is increased during neuropathic pain. TNF-alpha regulates the expression of Klf15. KLF15 regulates the expression of dopamine D2 receptor. KLF15 regulates neuropathic pain in mouse models. PMID: 28830816
    8. Kruppel-like factor 15 (KLF15) governs a biphasic transcriptomic oscillation in the heart with a maximum ATP production phase and a remodeling and repair phase corresponding to the active and resting phase of a rodent. PMID: 26686628
    9. deletion of Klf15 interferes with nuclear control of mitochondrial fission, whereas fusion appears to be unaffected. PMID: 26111268
    10. Our results demonstrate that c-Jun can suppress adipocyte differentiation through the down-regulation of KLF15 at the transcriptional level. PMID: 26692489
    11. KLF15 regulates bile acid synthesis via negative regulation of circadian Fgf15 expression. PMID: 26040986
    12. Adipolin is transcriptionally regulated by KLF15 in adipocytes. PMID: 24358263
    13. KLF15 upregulated slow myosin heavy chain expression through NFATc1. PMID: 24680826
    14. This study establishes KLF15 as an important molecular link between ER stress and insulin action. PMID: 24167585
    15. KLF15 as a key regulator of myocardial lipid utilization and is the first to implicate the KLF transcription factor family in cardiac metabolism. PMID: 24407292
    16. IL-17 suppresses expression of PPARgamma, C/EBPalpha, KLF15, a pro-adipogenic transcription factor, and enhances expression of KLF2 and KLF3, which are anti-adipogenic. PMID: 23332504
    17. The glucocorticoid receptor and KLF15 regulate gene expression dynamics, providing a novel mechanism for temporal control and signal integration by glucocorticoid receptor. PMID: 23508109
    18. Via inhibition of beta-catenin transcription, KLF15 controls cardiac progenitor cell homeostasis in the adult heart similar to embryonic cardiogenesis. PMID: 22767436
    19. a critical role of KLF15 in mediating podocyte differentiation and in protecting podocytes against injury. PMID: 22493483
    20. KLF15 is therefore a downstream physiological mediator of progesterone's cell cycle inhibitory action in the uterine epithelium. PMID: 22538816
    21. Nitrogen homeostasis exhibits circadian rhythmicity, and is orchestrated by Kruppel-like factor 15. PMID: 22405069
    22. Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion. PMID: 21862590
    23. the GR target, Klf15, has a role in modulating airway function PMID: 21257922
    24. Kruppel-like factor 15 activates hepatitis B virus gene expression and replication. PMID: 21503941
    25. Deficiency of the transcriptional regulator Kruppel-like factor 15 (Klf15) in mice leads to both heart failure and aortic aneurysm and Klf15 concentrations are markedly reduced in failing human hearts and in human aortic aneurysm tissues. PMID: 20375365
    26. Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity. PMID: 20566642
    27. Identify KLF15 as a novel inhibitor of vascular smooth muscle cell proliferation and migration and to implicate this factor as a critical regulator of the vascular response to injury. PMID: 20508206
    28. KLF15 plays an important role in regulation of the expression of genes for gluconeogenic and amino acid-degrading enzymes PMID: 20393151
    29. KLF15 plays an essential role in adipogenesis in 3T3-L1 cells through its regulation of PPAR gamma expression PMID: 15664998
    30. KLF15 plays an important role in the regulation of gluconeogenesis. PMID: 17403374
    31. These studies identify KLF15 as part of a heretofore unrecognized pathway regulating the cardiac response to hemodynamic stress PMID: 17438289
    32. These results thus implicate KLF15 in the regulation of adrenomedullin expression in adipose tissue. PMID: 19094967

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in aortic smooth muscle cells.
  • 数据库链接：

    KEGG: mmu:66277

    STRING: 10090.ENSMUSP00000032174

    UniGene: Mm.38343