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  4. Recombinant Mouse Jun dimerization protein 2 (Jdp2)

Recombinant Mouse Jun dimerization protein 2 (Jdp2)

  • 中文名称：
    小鼠Jdp2重组蛋白
  • 货号：
    CSB-YP011945MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Jdp2重组蛋白
  • 货号：
    CSB-EP011945MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Jdp2重组蛋白
  • 货号：
    CSB-EP011945MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Jdp2重组蛋白
  • 货号：
    CSB-BP011945MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Jdp2重组蛋白
  • 货号：
    CSB-MP011945MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Jdp2
  • Uniprot No.：
  • 别名：
    Jdp2; Jundm2; Jun dimerization protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-163
  • 氨基酸序列
    MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL QRESERLELM NAELKTQIEE LKLERQQLIL MLNRHRPTCI VRTDSVRTPE SEGNPLLEQL DKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
  • 基因功能参考文献：
    1. Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH and higher expression of the Fshb subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles PMID: 28007961
    2. JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. PMID: 28146118
    3. High JDP2 expression in the bone marrow contributes to metastatic spread in the lung. PMID: 26497998
    4. results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway PMID: 25026555
    5. Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2. PMID: 24394418
    6. Using transgenic mice overexpressing the AP-1 inhibitor JDP2, a central role of AP-1 in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated. PMID: 23612584
    7. Jdp2 transcriptionally regulates the Trp53 promoter, via an atypical AP-1 site, and Jdp2 expression negatively regulates Trp53 expression levels; a genetic mechanism for tumour formation in the context of Trp53 heterozygosity PMID: 22370638
    8. the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism. PMID: 22989952
    9. Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation. PMID: 23200825
    10. JDP2 phosphorylation by JNK results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli PMID: 21463260
    11. transcription of the gene for cyclin-A2 appears to be a direct target of JDP2 in the suppression of cell proliferation PMID: 20802531
    12. JDP2 expression may play a critical role in liver cancer development. PMID: 20214788
    13. JDP2, repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.JDP2 is key factor that controls the commitment of F9 cells to differentiation and shed light on AP-1 repressor functions PMID: 12052888
    14. JDP2 protein plays a major role in promoting skeletal muscle differentiation via its involvement in cell cycle arrest and activation of the myogenic program PMID: 12171923
    15. characterization of binding sites for stress mitogen-activated protein kinases on JDP2 PMID: 12225289
    16. Results suggest that Jun dimerization protein 2 (JDP2) may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation. PMID: 12707301
    17. c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene PMID: 14627710
    18. Fos/Jdp2/Batf locus is associated with SL3-3 mouse leukemia virus B cell lymphoma. PMID: 15913695
    19. JDP2 inhibited both the acetylation of histone H3 in the promoter of the gene for C/EBPdelta and transcription from this promoter. PMID: 17464331
    20. Results indicate that JDP2 is involved in the signaling pathway for senescence via epigenetic regulation of the expression of the gene for p16(Ink4a). PMID: 19233846

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 组织特异性：
    Ubiquitously expressed in all adult tissues tested as well in embryos.
  • 数据库链接：

    KEGG: mmu:81703

    STRING: 10090.ENSMUSP00000059724

    UniGene: Mm.103560