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  4. Recombinant Mouse Interferon-induced protein with tetratricopeptide repeats 2 (Ifit2)

Recombinant Mouse Interferon-induced protein with tetratricopeptide repeats 2 (Ifit2)

  • 中文名称：
    小鼠Ifit2重组蛋白
  • 货号：
    CSB-YP011021MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ifit2重组蛋白
  • 货号：
    CSB-EP011021MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ifit2重组蛋白
  • 货号：
    CSB-EP011021MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ifit2重组蛋白
  • 货号：
    CSB-BP011021MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ifit2重组蛋白
  • 货号：
    CSB-MP011021MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ifit2
  • Uniprot No.：
  • 别名：
    Ifit2; Garg39; Ifi54; Isg54; Interferon-induced protein with tetratricopeptide repeats 2; IFIT-2; Glucocorticoid-attenuated response gene 39 protein; GARG-39; Interferon-induced 54 kDa protein; IFI-54K; P54
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-472
  • 氨基酸序列
    STTSKESLV CNLRQLKCHF TWNLIAEDES LDEFEDRVFN KDEFQNSEFK ATMCNILAYV KHCRGLNEAA LQCLGEAEGF IQQQHPDQVE IRSLVTWGNY AWVYYHMGQF SKAQAYLDKV KQVCKKFSSP YRIENPALDC EEGWARLKCT KNQNERVKVC FQKALEKDPK NPEFTSGWAI AFYRLDDWPA RNYCIDSLEQ AIQLSPDNTY VKVLLALKLD AVHVHKNQAM ALVEEALKKD PSAIDTLLRA ARFYCKVYDT DRAIQLLRKA LEKLPNNAYV HYYMGCCYRS KVHHMLNRRE MVFSGDRKKL EELIQLAVNH LRKAEEIKEM LEYSCSFLAD LYIIAKKYDE ADYYFQKELS KDLPPGPKQL LHLRYGNFQF FQMKRQDKAI YHYMEGVKIK KKTIPQKKMR EKLQRIALRR LHEDESDSEA LHILAFLQEN GGGQQADKDS ERGVDSANQV PSASLDEDGA EY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
  • 基因功能参考文献：
    1. this study shows that activation of IRF3 contributes to IFN-gamma and ISG54 expression during the immune responses to B16F10 tumor growth PMID: 28651122
    2. Ifit2 exerts its antiviral effect mainly at the level of viral replication, as opposed to functioning as a mechanism that restricts viral entry/egress or transports rabies virus particles through axons. PMID: 28637751
    3. These results indicate that high Sendai virus replication in the lungs of infected Ifit2(-/-) mice cooperates with elevated IFN-beta induction to cause disease. PMID: 25231314
    4. Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus. PMID: 24991014
    5. Ifit2 is a positive regulator of IFN-alpha/beta expression during mouse hepatitis virus induced encephalitis. PMID: 24198415
    6. IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-alpha secretion and LPS-induced endotoxin shock. PMID: 24014876
    7. These results suggest that Ifit2 restricts West Nile virus infection and pathogenesis in different tissues in a cell type-specific manner. PMID: 23740986
    8. results indicate that in the brain, but not in other organs, Ifit2 is a major mediator of IFN's protective effect against VSV PMID: 22615570
    9. Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection. PMID: 22065572
    10. IFIT-2 may affect selectively LPS induced protein expression probably by regulation at different posttranscriptional levels PMID: 19108715
    11. IFIT2/GARG39 was identified as a microtubule-associated protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10 melanoma cells. PMID: 17030862

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum.
  • 蛋白家族：
    IFIT family
  • 数据库链接：

    KEGG: mmu:15958

    STRING: 10090.ENSMUSP00000099890

    UniGene: Mm.2036