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  4. Recombinant Mouse Insulin-like growth factor-binding protein 3 (Igfbp3)

Recombinant Mouse Insulin-like growth factor-binding protein 3 (Igfbp3)

  • 中文名称：
    小鼠Igfbp3重组蛋白
  • 货号：
    CSB-YP011097MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Igfbp3重组蛋白
  • 货号：
    CSB-EP011097MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Igfbp3重组蛋白
  • 货号：
    CSB-EP011097MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Igfbp3重组蛋白
  • 货号：
    CSB-BP011097MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Igfbp3重组蛋白
  • 货号：
    CSB-MP011097MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Igfbp3; Igfbp-3; Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-292
  • 氨基酸序列
    GAG AVGAGPVVRC EPCDARALSQ CAPPPTAPAC TELVREPGCG CCLTCALREG DACGVYTERC GTGLRCQPRP AEQYPLRALL NGRGFCANAS AAGSLSTYLP SQPAPGNISE SEEEHNAGSV ESQVVPSTHR VTDSKFHPLH AKMDVIKKGH ARDSQRYKVD YESQSTDTQN FSSESKRETE YGPCRREMED TLNHLKFLNV LSPRGVHIPN CDKKGFYKKK QCRPSKGRKR GFCWCVDKYG QPLPGYDTKG KDDVHCLSVQ SQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.
  • 基因功能参考文献：
    1. Igfbp3-null mouse model was generated in combination with Kras(G12D) to compare the tumor burden. Then, IGF-dependent signaling was assessed after expressing wild-type or a mutant IGFBP3 without IGF binding capacity in non-small cell lung cancer (NSCLC) cells PMID: 28330997
    2. endogenous (circulating and/or stromal) IGFBP-3 is stimulatory to adipose tissue expansion and enhances mammary tumor growth in immune-competent mice, potentially by suppressing T-cell infiltration into tumors. PMID: 27448965
    3. High Igfbp3 expression is associated with skin squamous cell carcinoma. PMID: 28807942
    4. The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt pathway and depends upon the presence of CD44, a receptor protein known to modulate Wnt signaling. PMID: 27377812
    5. IGFBP-3 influences severity of DSS-induced colitis. PMID: 27253188
    6. our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain PMID: 28088287
    7. IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury. PMID: 26073647
    8. An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage. PMID: 25082650
    9. Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis. PMID: 25614235
    10. Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC migration. PMID: 24358328
    11. IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy. PMID: 22792172
    12. IGFBP-3 activates inhibitory Smad signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta. PMID: 22910030
    13. Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. PMID: 22034491
    14. IGFBP-3 positively and negatively impacts on IGF1-induced lung cancer development. PMID: 21447628
    15. Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. PMID: 21697095
    16. Mice genetically deficient in IGFBP-3 have weaker growth of primary prostate tumors but higher incidence of metastases. PMID: 21697285
    17. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease. PMID: 21383009
    18. IGFBP-3 has a role in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury PMID: 21435441
    19. The s showed that expression of insulin-like growth factor binding protein 3 mRNA increases not only in Borna disease virus P-expressing cultured cells but also in astrocytes from the cerebella of P transgenic mice. PMID: 21325425
    20. Association between Igfbp3 and risk of prostatic cancer are examined. PMID: 20473871
    21. This study provides evidence that genetic deletion of IGFBP-3 modulates hepatic carbohydrate and lipid metabolism. PMID: 20926583
    22. Data indicate that impairment of IGF-1 complex formation with insulin-like growth factor binding protein, acid labile subunit in bone marrow alters cell fate, leading to increased adipogenesis. PMID: 20007694
    23. IGFBP3 and Humanin play key roles in the coordinated regulation of testicular germ cell homeostasis. PMID: 19952275
    24. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa. PMID: 19777566
    25. response to nutritional stsatus chanes in PPARalpha knockout mice PMID: 11735249
    26. overexpression of hIGFBP-3 results in fasting hyperglycemia, impaired glucose tolerance, and insulin resistance. PMID: 12376320
    27. IGFBP-3 increases osteoclast number and bone resorption, impairs osteoblast proliferation, and has a significant negative effect on bone formation PMID: 14584894
    28. N- and C-terminal residues of IGFBP-3 have roles in regulating IGF complex formation and receptor activation PMID: 15485880
    29. the growth inhibitory effect of mutant IGFBP-3 may be compensated for by other mechanisms PMID: 15550509
    30. IGFBP-3 induces apoptosis through an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77 PMID: 15731112
    31. Overexpression of Hbegf in transgenic mice downregulates Igfbp3. PMID: 16019424
    32. Igfbp3 modulates cell proliferation in the hair follicle. PMID: 16185287
    33. IGFBP-3 is upregulated by apigenin in a pathway leading to cancer growth inhibition and apoptosis PMID: 16230333
    34. the IGF-independent effects of IGFBP-3 may be important in inhibiting tumor progression PMID: 16469805
    35. IGFBP-3 is a growth inhibitor molecule (news) PMID: 16617154
    36. provide direct evidence for combinatorial effects of IGFBP-3, -4, and -5 in both metabolism and at least some soft tissues PMID: 16675541
    37. IGFBP-3 has direct, IGF-independent inhibitory effects on angiogenesis providing an additional mechanism by which it exerts its tumor suppressive effects PMID: 16983336
    38. IGFBP3 is a downstream gene regulated by MeCP2 and MeCP2 may contribute directly to the transcriptional expression of IGFBP3 in the brain. PMID: 17278996
    39. In summary, the absence of the IGFBP-5 gene did not block the ability of IGF-I to stimulate intestinal growth, possibly because greater jejunal expression of IGFBP-3 compensates for the absence of IGFBP-5. PMID: 17332154
    40. IGFBP-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms PMID: 17388800
    41. Igfbp3 regulates hematopoietic stem cell and endothelial precurosr cell function during vascular development. PMID: 17567755
    42. Igfbp3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. PMID: 17567756
    43. SRC-3 maintains IGF-I in the circulation through enhancing VDR-regulated IGFBP-3 expression. PMID: 18212051
    44. Data suggest that loss of expression of IGFBPs (IGFBP-3 and IGFBP-4) in tumor cells treated with EGFR tyrosine kinase inhibitors derepresses IGFIR signaling, which in turn mediates resistance to EGFR antagonists. PMID: 18568074
    45. IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children. PMID: 18924579
    46. IGFBP-3 inhibits adipocyte differentiation. PMID: 19141684
    47. IGFBP3 is a new regulator of hypocretin cell physiology that may be involved not only in the pathophysiology of narcolepsy, but also in the regulation of sleep in normal individuals, most notably during adolescence PMID: 19158946
    48. IGFBP-3 binds to fibronectin cell binding domain. PMID: 19236847
    49. These studies reveal multisite phosphorylation of IGFBP-3 that both positively and negatively regulate its apoptotic potential. PMID: 19556345
    50. IGFBP-3 mediated chondrocyte apoptosis is regulated by Gli2 and p53 in the progression from benign to malignant cartilage tumors. PMID: 19647223

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:16009

    STRING: 10090.ENSMUSP00000020702

    UniGene: Mm.29254