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  4. Recombinant Mouse Insulin-like growth factor-binding protein 1 (Igfbp1)

Recombinant Mouse Insulin-like growth factor-binding protein 1 (Igfbp1)

  • 中文名称：
    小鼠Igfbp1重组蛋白
  • 货号：
    CSB-BP011095MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Igfbp1重组蛋白
  • 货号：
    CSB-EP011095MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Igfbp1重组蛋白
  • 货号：
    CSB-MP011095MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Name:Igfbp1 Synonyms:Igfbp-1
  • Uniprot No.：
  • 别名：
    Igfbp1; Igfbp-1; Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-272
  • 氨基酸序列
    APQPW HCAPCTAERL GLCPPVPASC PEISRPAGCG CCPTCALPMG AACGVATARC AQGLSCRALP GEPRPLHALT RGQGACVPEP AAPATSTLFS SQHEEAKAAV VSADELSESP EMTEEQLLDS FHLMAPSRED QPILWNAIST YSSMRAREIA DLKKWKEPCQ RELYKVLERL AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK KIPGSLETRG DPNCHQYFNV HN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
  • 基因功能参考文献：
    1. the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss PMID: 26456333
    2. Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha). PMID: 25869614
    3. serum IGFBPI protein could provide an easily measured biomarker for early detection of alcohol-induced liver injury in humans PMID: 24152801
    4. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. PMID: 22843786
    5. Global deletion of Igfbp1 in a c-Myc transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass. PMID: 21903863
    6. IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals PMID: 12511596
    7. IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBP beta activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways. PMID: 12556485
    8. Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. PMID: 15862298
    9. high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model PMID: 16293667
    10. the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors PMID: 17062566
    11. IGFBP-1 may have an important regulatory role in vivo and in the pathogenesis of type 2 diabetes, in which loss of insulin release is an early pathogenetic event PMID: 17693389
    12. Ahr regulates Igfbp-1 and Lpl expression in the liver. TCDD treatment did not increase the Igfbp-1 and Lpl mRNA levels in Ahr knockout mice. PMID: 18827440
    13. the embryopathic effects are associated with knockdown of EGNL1 and the associated induction of Igfbp1 mRNA in the placenta, but not the embryo. PMID: 19683511

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:16006

    STRING: 10090.ENSMUSP00000020704

    UniGene: Mm.21300