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  4. Recombinant Mouse Homeodomain-only protein (Hopx)

Recombinant Mouse Homeodomain-only protein (Hopx)

  • 中文名称：
    小鼠Hopx重组蛋白
  • 货号：
    CSB-YP840268MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hopx重组蛋白
  • 货号：
    CSB-EP840268MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hopx重组蛋白
  • 货号：
    CSB-EP840268MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hopx重组蛋白
  • 货号：
    CSB-BP840268MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hopx重组蛋白
  • 货号：
    CSB-MP840268MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hopx
  • Uniprot No.：
  • 别名：
    Hopx; Hod; Hop; Ob1; Homeodomain-only protein; Homeobox-only protein; Odd homeobox protein 1; mOB1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-73
  • 氨基酸序列
    MSAQTASGPT EDQVEILEYN FNKVNKHPDP TTLCLIAAEA GLTEEQTQKW FKQRLAEWRR SEGLPSECRS VTD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
  • 基因功能参考文献：
    1. Analysis of the hematopoietic stem/progenitor cell pool in Hopx-/- mice demonstrated significantly reduced cell frequencies and impaired engraftment in competitive repopulation assays, thus providing functional validation of this positional candidate gene PMID: 26050929
    2. Type I alveolar cells expressing Hopx manifest plasticity to regenerate type II alveolar cells in the lung. PMID: 25865356
    3. Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression. PMID: 26170384
    4. Hopx integrates Bmp and Wnt signaling by physically interacting with activated Smads and repressing Wnt genes. PMID: 26113728
    5. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. PMID: 23487314
    6. HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure. PMID: 21382376
    7. Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas-induced apoptosis. PMID: 21061432
    8. Hopx is required for the function of regulatory T cells induced by DCs and the promotion of DC-mediated T cell unresponsiveness in vivo. PMID: 20802482
    9. Hdac2, Hopx, and Gata4 coordinately regulate cardiac myocyte proliferation during embryonic development. PMID: 20833366
    10. Expressed in embryonic myocardium and other mesoderm, but not in endocardium or great vessels. PMID: 12617835
    11. data show that Hop can inhibit serum response factor-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity and can form a complex that includes HDAC2 PMID: 12975471
    12. Hop functions in the adult cardiac conduction system and demonstrate conservation of molecular hierarchies between embryonic myocardium and the specialized conduction tissue of the mature heart. PMID: 15790958
    13. Hop is regulated in the forebrain by a so far unidentified paracrine signaling factor from the roof plate PMID: 15967424
    14. Expression pattern of Hop provides first evidence that new transcription is initiated in lens fiber cells after they detach from the capsule. Hop may be first of class of genes with this pattern of expression. PMID: 17277742
    15. HOP/NECC1 (-/-) placenta exhibited marked propagation of giant cell layers and, in turn reduction of spongiotrophoblast formation PMID: 17576768
    16. HOP participates in the regulation of the adult mouse hippocampal stem cell niche by negatively affecting cell survival PMID: 18507846
    17. HOP is highly expressed in the developing heart, dependent on the cardiac-restricted homeodomain protein Nkx2.5. Mice homozygous for a HOP null allele segregate into two phenotypic classes characterized by an excess or deficiency of cardiac myocytes. PMID: 12297046
    18. Inactivation of Hop in mice by homologous recombination results in a partially penetrant embryonic lethal phenotype with severe developmental cardiac defects involving the myocardium. PMID: 12297045

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen. Throughout embryonic and postnatal development, it is expressed in the myocardium.
  • 数据库链接：

    KEGG: mmu:74318

    STRING: 10090.ENSMUSP00000080630

    UniGene: Mm.181852