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  4. Recombinant Mouse Homeobox protein Hox-B4 (Hoxb4)

Recombinant Mouse Homeobox protein Hox-B4 (Hoxb4)

  • 中文名称：
    小鼠Hoxb4重组蛋白
  • 货号：
    CSB-YP010664MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxb4重组蛋白
  • 货号：
    CSB-EP010664MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxb4重组蛋白
  • 货号：
    CSB-EP010664MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxb4重组蛋白
  • 货号：
    CSB-BP010664MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxb4重组蛋白
  • 货号：
    CSB-MP010664MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxb4
  • Uniprot No.：
  • 别名：
    Hoxb4; Hox-2.6; Hoxb-4; Homeobox protein Hox-B4; Homeobox protein Hox-2.6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-250
  • 氨基酸序列
    MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESGFQP EAAFGRRAPC TVQRYAACRD PGPPPPPPPP PPPPPPGLSP RAPVQPTAGA LLPEPGQRSE AVSSSPPPPP CAQNPLHPSP SHSACKEPVV YPWMRKVHVS TVNPNYAGGE PKRSRTAYTR QQVLELEKEF HYNRYLTRRR RVEIAHALCL SERQIKIWFQ NRRMKWKKDH KLPNTKIRSG GTAGAAGGPP GRPNGGPPAL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Our data reveal a route to establishing functional multipotent HSCs that exploits aspects of in vitro differentiation, transcription factor re-specification with HoxB4 to enhance self-renewal, and Notch-mediated lineage specification PMID: 28009288
    2. can amplify long-term repopulating hematopoietic stem cells in a controlled way. This characteristic depends on a proline-rich sequence near the N terminus, which is unique among HOX genes and highly conserved in higher mammals PMID: 27827825
    3. Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects. PMID: 24446131
    4. these studies define the transcriptional pathways involved in HOXB4 HSC expansion in vivo and identify repression of Prdm16 transcription as a mechanism by which expanding HSCs avoid leukemic transformation. PMID: 25082879
    5. Hoxb4 favours the maintenance and increase of the CD4 central memory phenotype T cell population. PMID: 24324706
    6. HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation. PMID: 22084016
    7. HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing hematopoietic stem cells into repopulating cells PMID: 21343615
    8. Hoxb4 expression therefore would not appear to correlate with the cycling status of fetal liver hematopoietic stem cells(HSCs), although highly proliferative HSCs from young BM show strong Hoxb4 expression. PMID: 21278354
    9. Data suggest that transduced Hoxb4 down-regulates Geminin protein probably by constituting the E3 ubiquitin ligase for Geminin to provide hematopoietic stem and progenitor cells with proliferation potential. PMID: 21098278
    10. Results compare the hematopoietic inductive effects of stromal cell lines derived from different subregions of the embryonic aorta-gonad-mesonephros tissue with the commonly used OP9 stromal cell line and with HOXB4 activation. PMID: 20184433
    11. Primitive hematopoietic stem cells (HSCs) are poised to become definitive adult HSCs and this transition can be promoted by HoxB4 expression. PMID: 11955444
    12. relative levels of NFY and YY1 binding could represent a mechanism for balancing activation and repression of Hoxb4 through the same site PMID: 12135926
    13. NF-Y is a developmentally regulated inducer of the HOXB4 gene in hematopoietic cells. PMID: 12791656
    14. p38 mitogen-activated protein kinase (MAPK) was responsible for the TPO-induced Hoxb4 elevation PMID: 12855555
    15. the deficiency of Hoxb4 leads to hypocellularity in hematopoietic organs and impaired proliferative capacity but Hoxb4 is not required for the generation of HSCs or the maintenance of steady state hematopoiesis. PMID: 14962901
    16. Immunohistochemical analysis of transverse spinal cord sections demonstrated diffuse expression of Hoxb4 throughout the spinal cord at E12.5, after which expression was confined primarily to the presumptive gray matter. PMID: 15206819
    17. increased HOXB4 expression was paralleled by decreased expression levels of cyclins, Cyclin-Dependent Kinases and AP-1 family members PMID: 15580301
    18. a new molecular link, completing a feedback circuit between retinoic acid receptor beta, Hoxb4 and Hoxd4 PMID: 15634700
    19. HOXB4 enforces equivalent fates of embryonic stem-cell-derived and adult hematopoietic cells. PMID: 16093308
    20. Our results show that Hoxb4(-/-) and Hoxb1-b9 (-/-) fetal liver cells retain full competitive repopulation potential and the ability to regenerate all myeloid and lymphoid lineages. PMID: 16339407
    21. These results strongly suggest that HOXB4 modulates the response of HSCs to multiple extrinsic signals in a concerted manner, thereby shifting the balance toward stem cell self-renewal. PMID: 17940039
    22. Evidence for Hoxb4 and E2A-PBX1 collaboration in mouse T- cell leukemia is reported. PMID: 18679416
    23. All Hox paralog group 4 members, A4, B4, C4, and D4, have similar effects on hematopoietic stem and progenitor self-renewal in vitro. PMID: 18808325
    24. physiologic effects of HOXB4 on TNF-alpha sensitivity and the relationship of these effects to the engraftment defect of Fanconi anemia HSCs PMID: 19270262
    25. Data show that Prep1 and 4EHP co-localize in the cytosol of growing mouse oocytes, and that Prep1 binds the Hoxb4 3'UTR to inhibit its translation. PMID: 19365557

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Deformed subfamily
  • 数据库链接：

    KEGG: mmu:15412

    STRING: 10090.ENSMUSP00000048002

    UniGene: Mm.3546