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  4. Recombinant Mouse Homeobox protein Hox-A9 (Hoxa9)

Recombinant Mouse Homeobox protein Hox-A9 (Hoxa9)

  • 中文名称：
    小鼠Hoxa9重组蛋白
  • 货号：
    CSB-YP010658MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxa9重组蛋白
  • 货号：
    CSB-EP010658MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxa9重组蛋白
  • 货号：
    CSB-EP010658MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxa9重组蛋白
  • 货号：
    CSB-BP010658MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxa9重组蛋白
  • 货号：
    CSB-MP010658MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxa9
  • Uniprot No.：
  • 别名：
    Hoxa9; Hox-1.7; Hoxa-9; Homeobox protein Hox-A9; Homeobox protein Hox-1.7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-271
  • 氨基酸序列
    MATTGALGNY YVDSFLLGAD AADELGAGRY APGTLGQPPR QAAALAEHPD FSPCSFQSKA AVFGASWNPV HAAGANAVPA AVYHHHHHPY VHPQAPVAAA APDGRYMRSW LEPTPGALSF AGLPSSRPYG IKPEPLSARR GDCPTLDTHT LSLTDYACGS PPVDREKQPS EGAFSENNAE NESGGDKPPI DPNNPAANWL HARSTRKKRC PYTKHQTLEL EKEFLFNMYL TRDRRYEVAR LLNLTERQVK IWFQNRRMKM KKINKDRAKD E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.
  • 基因功能参考文献：
    1. The analysis points to a critical role for Hoxa9 and PU.1 in distal regulation of c-myb expression in murine myeloid cells during iL-6-induced cell differentiation. PMID: 27607579
    2. data delineate an altered epigenetic stress response in activated satellite cells from aged mice, which limits satellite cell function and muscle regeneration by Hoxa9-dependent activation of developmental pathways PMID: 27919074
    3. Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein. PMID: 25911551
    4. IGF-1 is a direct HOXA9 target important for hematopoietic transformation. PMID: 25252870
    5. deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis PMID: 24809472
    6. This is the first description of a molecular link between HoxA9 and the regulation of Bcl-2 family members in acute myeloid leukemia. PMID: 24177192
    7. HOXA9 may, therefore, stimulate ovarian cancer progression by promoting an immunosuppressive microenvironment via paracrine effects on peritoneal macrophages. PMID: 24332016
    8. High Hoxa9 transgene expression in the embryonic hematopoietic compartment was lethal. Mice with lower levels of Hoxa9 developed a precursor-T-cell lymphoblastic leukemia/lymphoma, accompanied by spontaneous Notch1 mutations. PMID: 23435313
    9. These findings reveal distinct requirements for Hoxa9 or Hoxa9/Flt3 molecular circuits in regulation of B versus natural killer and dendritic cell development in bone marrow. PMID: 23363389
    10. Collectively, our data suggest that PBX3 is a critical cofactor of HOXA9 in leukemogenesis. PMID: 23264595
    11. Loss of Scmh1 caused derepression of Hoxb4 and Hoxa9, direct targets of Polycomb-group complex 1-mediated transcriptional silencing in hematopoietic cells. PMID: 23207902
    12. Female nude mice inoculated i.p. with MOSEC cells that overexpressed Hoxa9 developed larger tumors and had significantly shorter survival times than controls. PMID: 22945634
    13. Our data suggest that the presence of a GFI136N variant allele induces a preleukemic state in myeloid precursors by deregulating the expression of Hoxa9 and other AML-related genes. PMID: 22932805
    14. The Hoxa9 regulates expression of p16(Ink4a)/p19(ARF) locus and could overcome senescence induced by AML1-ETO. PMID: 21624810
    15. Specific recruitment of MLL1 requires multiple interactions and is a precondition for stable recruitment of MLL1 fusion proteins to HoxA9 in leukemogenesis. PMID: 20541448
    16. molecular crosstalk between aberrant expression of Hox molecule(s) and activated Raf may have a key role in the MLL-fusion-mediated-leukemogenesis PMID: 19710696
    17. A mouse model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 PMID: 12032333
    18. HOXA9 complexed with PBX1 and DNA, so that the posterior HOX hexapeptide adopts an altered conformation. PMID: 12923056
    19. Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia PMID: 14615372
    20. Hoxa9 and Hoxa7 as well as the Hox coregulators Meis1 and Pbx3 among the targets upregulated by MLL-ENL-ERtm in conditionally transformed cells PMID: 14701735
    21. These data suggest that phorbol ester-induced myeloid differentiation is in part due to protein kinase C-mediated phosphorylation of HOXA9, which decreases the DNA binding of the homeoprotein. PMID: 15082777
    22. HOXA9 nuclear transport is induced by thrombopoietin in immature hematopoietic cells PMID: 15254242
    23. the fusion VP16-Meis1 is spontaneously oncogenic, and leukemias harbor genetic activation of endogenous Hoxa9 and/or Hoxa7, suggesting that Hoxa gene activation represents a key event required for the oncogenic activity of VP16-Meis1 PMID: 16469876
    24. These results suggest that c-Myb is essential but not sufficient for Hoxa9/Meis1 mediated transformation. PMID: 16507773
    25. Persistent transactivation by Meis1 replaces hoxa9 function in myeloid leukemogenesis models. PMID: 16648484
    26. Mice reconstituted with HSC cotransduced with HoxA9 and Trib2 had accelerated onset of AML compared to either gene alone PMID: 17988908
    27. Evidence for Hoxa9 and E2A-PBX1 collaboration in T-cell leukemia is reported. PMID: 18679416
    28. The block in differentiation of Men1(-/-) embryonic stem cell lines can be rescued not only by the expression of menin but also that of Hoxa9. PMID: 19393316
    29. CREB1 may mediate HOXA9 modulation of Meis1 expression. PMID: 19620287

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 组织特异性：
    Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region.
  • 数据库链接：

    KEGG: mmu:15405

    STRING: 10090.ENSMUSP00000046939

    UniGene: Mm.4694