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  4. Recombinant Mouse High mobility group protein B2 (Hmgb2)

Recombinant Mouse High mobility group protein B2 (Hmgb2)

  • 中文名称：
    小鼠Hmgb2重组蛋白
  • 货号：
    CSB-YP010560MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hmgb2重组蛋白
  • 货号：
    CSB-EP010560MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hmgb2重组蛋白
  • 货号：
    CSB-EP010560MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hmgb2重组蛋白
  • 货号：
    CSB-BP010560MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hmgb2重组蛋白
  • 货号：
    CSB-MP010560MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hmgb2
  • Uniprot No.：
  • 别名：
    Hmgb2; Hmg2; High mobility group protein B2; High mobility group protein 2; HMG-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-210
  • 氨基酸序列
    MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF EDLAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSENR PKIKIEHPGL SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG SKKKNEPEDE EEEEEEEEEE DDEEEEEDEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway.
  • 基因功能参考文献：
    1. HMGB2 expression is strongly associated with transition from the quiescent to the proliferative state of neural stem cells, supporting the possibility that HMGB2 is involved in the regulation of adult neurogenesis and can be used as a novel marker to identify neural stem cells primed for activation in the adult hippocampus. PMID: 28771884
    2. these results highlight the previously undiscovered and crucial role of the HMGB2-IGF2BP2 axis in myogenesis and muscle regeneration. PMID: 27672022
    3. HMGB2 promoted neointimal hyperplasia in mice with arterial wire injury through reactive oxygen species activation. PMID: 28183701
    4. data demonstrate a reciprocal relationship between Hmgb2 and Ctcf in controlling aspects of chromatin structure and gene expression. PMID: 27226577
    5. Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1. PMID: 25937287
    6. HMGB2 functions as a modulator of neurogenesis in young adult mice through regulation of neural stem cell proliferation. PMID: 24391977
    7. Oct4 post-translational modifications (PTMs) form a positive feedback loop, which promotes Akt activation and interaction with Hmgb2 and the SET complex. PMID: 23495099
    8. HMGB2 (but not HMGB1) suppresses pathologic cell growth in vivo and controls a gene expression program responsible for hypertrophic cell growth PMID: 22270000
    9. The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations. PMID: 21890638
    10. Data show that Hmgb1 and Hmgb2 function redundantly to enhance Wnt signaling in embryos, and further suggest that integrating Wnt, Shh, and BMP signaling regulates the development of digit5 in forelimbs. PMID: 21384471
    11. High levels of HMGB2 directly correlate with the extent of neoplastic changes in cutaneous squamous cell carcinoma. HMGB2 is an effective stimulus for cell differentiation, tumor progression, & metastatic invasion. PMID: 18798064
    12. In human and murine cartilage, there is an aging-related loss of HMGB2 expression, ultimately leading to its complete absence. PMID: 19139395
    13. Increased HMGB2 expression is associated with squamous cell carcinoma of skin. PMID: 19435426
    14. an interaction between HMGB2 and the Wnt/beta-catenin pathway regulates the maintenance of the superficial zone PMID: 19805379
    15. high-mobility group box (HMGB) proteins function as universal sentinels for nucleic acids PMID: 19890330

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  • 亚细胞定位：
    Nucleus. Chromosome. Cytoplasm. Secreted.
  • 蛋白家族：
    HMGB family
  • 组织特异性：
    Widely expressed in embryo. In adult mainly expressed in lymphoid organs and testes. Expressed in primary spermatocytes. Expressed in the superficial zone of articular cartilage.
  • 数据库链接：

    KEGG: mmu:97165

    STRING: 10090.ENSMUSP00000065940

    UniGene: Mm.276881