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  4. Recombinant Mouse Heat shock factor protein 4 (Hsf4)

Recombinant Mouse Heat shock factor protein 4 (Hsf4)

  • 中文名称：
    小鼠Hsf4重组蛋白
  • 货号：
    CSB-YP879492MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hsf4重组蛋白
  • 货号：
    CSB-EP879492MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hsf4重组蛋白
  • 货号：
    CSB-EP879492MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hsf4重组蛋白
  • 货号：
    CSB-BP879492MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hsf4重组蛋白
  • 货号：
    CSB-MP879492MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hsf4
  • Uniprot No.：
  • 别名：
    Hsf4; Heat shock factor protein 4; HSF 4; mHSF4; Heat shock transcription factor 4; HSTF 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-492
  • 氨基酸序列
    MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD QSRFAKEVLP QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE FQHPSFVRGR EQLLERVRRK VPALRGDDSR WRPEDLSRLL GEVQALRGVQ ESTEARLQEL RQQNEILWRE VVTLRQSHSQ QHRVIGKLIQ CLFGPLQTGP SSTGAKRKLS LMLDEGSACS ASAKFNACPV SGALLQDPYF IQSPLPETTL GLSPHRARGP IISDIPEDSP SPEGHRLSPS GGCRRVKGLA LLKEEPASPG GDGEAGLALA PNECDFCVTA PPPLPVAVVQ AILEGKGSYS PEGPRSVQQP EPRGPREVPD RGTLGLDRGN RSPESLLPPM LLRPAPETLE PVAPVDVLGP SLHGREWTLM DLDMELSLMQ PLAPETDEAE LTVKELNSSG VGKDHTLGTP LMLDVQADLE GAALSVPGAL TLYNVTESNA SYLDPGASPS SP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-binding protein that specifically binds heat shock promoter elements (HSE).; Transcriptional repressor.; Transcriptional activator.
  • 基因功能参考文献：
    1. a novel molecular mechanism of HSF4 in regulating lens epithelial cell homeostasis PMID: 27586257
    2. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. PMID: 26319152
    3. The deletion of Hsf4 affects the expression of many genes, such as Ubc, Ptgs2, Egr1 and Fos. These genes may be involved in the development of cataract. PMID: 26187041
    4. A novel regulatory mechanism between Hsf1 and Hsf4b in modulating lens epithelial cell homeostasis. PMID: 25601714
    5. Mutations in the DNA binding domain (DBD) of the heat shock transcription factor 4 (HSF4) are known to be associated with early childhood autosomal dominant lamellar cataract. PMID: 25168898
    6. This comparative analysis with CRYAB and HSP70 demonstrates that differential heat shock response is controlled by cell-type-dependent access of HSF1 and HSF4 to specific promoters, independent of the promoter architecture. PMID: 23264262
    7. Hsf4b is a novel downstream transcription factor of FGF2, and its transcription activity is associated with FGF2-modulated lens epithelial cell-fiber cell transition. PMID: 23200779
    8. Mutation in HSF4b abolishes its function. Loss of 132 amino acids from the COOH-terminus of a mouse cataract HSF4b(lop11) results in the failure of trimer formation and subsequent failure of target DNA binding and transactivation. PMID: 22162625
    9. These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation. PMID: 20219016
    10. Data reveal the lens-specific role of heat shock transcription factor 4 (HSF4), and indicate that HSF1 and HSF4 are involved in regulating expression of growth factor genes. PMID: 15483628
    11. HSF4 fulfills a central role in controlling spatial and temporal expression of genes critical for correct development and function of the lens. PMID: 15593327
    12. Molecular evaluation of Hsf4 revealed an early transposable element inserted in intron 9 leading to cataract formation. PMID: 16595169
    13. analysis of mechanisms of gene regulation controlled by HSF4 in non-classic heat shock response and in lens development PMID: 18755693
    14. disruption of the Hsf4 gene leads to cataracts via at least three pathways: down-regulation of gamma-crystallin, particularly gamma S-crystallin; decreased lens beaded filament expression; and loss of post-translational modification of alpha A-crystallin PMID: 19224648

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HSF family
  • 组织特异性：
    Preferentially expressed in brain and lung. Also found in the eye. Slightly detected in liver and skeletal muscle. Isoform B is the major species in various tissues.
  • 数据库链接：

    KEGG: mmu:26386

    STRING: 10090.ENSMUSP00000048904

    UniGene: Mm.89204