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Recombinant Mouse Guanylin (Guca2a)

  • 中文名称：
    小鼠Guca2a重组蛋白
  • 货号：
    CSB-YP010047MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Guca2a重组蛋白
  • 货号：
    CSB-EP010047MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Guca2a重组蛋白
  • 货号：
    CSB-EP010047MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Guca2a重组蛋白
  • 货号：
    CSB-BP010047MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Guca2a重组蛋白
  • 货号：
    CSB-MP010047MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Guca2a
  • Uniprot No.：
  • 别名：
    Guca2a; Guca2; Guanylin; Guanylate cyclase activator 2A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    102-116
  • 氨基酸序列
    PNTCEICAY AACTGC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
  • 基因功能参考文献：
    1. Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. PMID: 29289697
    2. guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage PMID: 27246004
    3. act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes PMID: 14675035
    4. These findings suggest that guanylin deficiency causes basal chloride secretion and reduced responsiveness to heat stable enterotoxin (STa) in mouse proximal colon. PMID: 15026148
    5. existence of two signaling pathways for guanylin peptides in principal cells of mouse cortical collecting duct of kidney PMID: 16105031

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Guanylin family
  • 组织特异性：
    Localized in both crypts and villi in the small intestine and to superficial epithelial cells in the colon.
  • 数据库链接：

    KEGG: mmu:14915

    STRING: 10090.ENSMUSP00000024015

    UniGene: Mm.2614