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  4. Recombinant Mouse Guanine nucleotide-binding protein G (o) subunit alpha (Gnao1)

Recombinant Mouse Guanine nucleotide-binding protein G (o) subunit alpha (Gnao1)

  • 货号：
    CSB-YP009593MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gnao1; Gna0; GnaoGuanine nucleotide-binding protein G(o) subunit alpha
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    42.0kDa
  • 表达区域：
    2-354aa
  • 氨基酸序列
    GCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear.
  • 基因功能参考文献：
    1. Galphao +/- mice developed tolerance faster and displayed more severe naltrexone-precipitated withdrawal in some behaviors than did wild-type PMID: 28971229
    2. Go signaling is essential for the structural and functional integrity of the main olfactory epithelium and for specification of olfactory bulb interneurons. PMID: 27625425
    3. Data obtained support the hypothesis that GalphaO-mediated signaling within the presympathetic circuits of the rostral ventral lateral medulla contributes to the autonomic control of the heart. PMID: 27528004
    4. Necdin is a candidate downstream effector for Galphao. PMID: 25012566
    5. This heterozygous Gnao1 +/G184S mutation produces early neonatal and adult lethality accompanied by epileptiform discharges. PMID: 24700286
    6. These results highlight that sensory neurons of the Galphao-expressing vomeronasal subsystem, together with the receptors they express and the molecular cues they detect, control a wide range of fundamental mating and reproductive behaviors in female mice. PMID: 24886577
    7. The Goalpha expressing vomeronasal receptor cells led to all areas of the accessory olfactory bulb (AOB). PMID: 22383629
    8. Data indicate that rectifying potassium channel Kir2.4 interacts with G-protein subunit Galphao. PMID: 23339194
    9. Data show that Galphao is an essential requirement for the display of male-male territorial aggression as well as maternal aggression. PMID: 21768373
    10. Data suggest that the novel R234H mutation imparts oncogenic properties to Galphao by accelerating nucleotide exchange and rendering it constitutively active. PMID: 21317923
    11. The 2.9 A crystal structure of the enigmatic, neuronal G protein Galpha(o) in the GTP hydrolytic transition state, complexed with RGS16. PMID: 18434540
    12. Go alpha subunit mainly appears to be bound to the cell membrane and concentrated in the thin finger-like dendrites of rod bipolar cells, as well as in green fluorescent protein-positive cone bipolar cells. PMID: 12454992
    13. Binding of activated Galphao to GRIN1 induces activation of Cdc42, which leads to morphological changes in neuronal cells. PMID: 15585744
    14. our findings establish an essential role for G(o) in the antiadrenergic effect of muscarinic agent on hyperpolarization current PMID: 18156202
    15. Go2alpha optimizes vesicular filling which is instrumental for normal dopamine functioning and for the development of drug-induced behavioral sensitization. PMID: 18606864
    16. Data show that Galphao colocalized with GRIN1 at neuronal dendrites and axons, and Galphao-GRIN1 pathway could mediate roles in neuronal migration and differentiation at embryonic stages. PMID: 18729205
    17. Report role of Galpha0 in the control of in vivo heart rate dynamics. PMID: 18832081
    18. Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. PMID: 19225179
    19. The G alpha(o) protein in the locus coeruleus as contributing to interindividual variability in physical dependence on opioids in mice. PMID: 19460419
    20. Data indicate that MC4R mutant is able to selectively interact with G(i/o) proteins. PMID: 19648111

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  • 亚细胞定位：
    Cell membrane. Membrane; Lipid-anchor.
  • 蛋白家族：
    G-alpha family, G(i/o/t/z) subfamily
  • 数据库链接：

    KEGG: mmu:14681

    STRING: 10090.ENSMUSP00000034198

    UniGene: Mm.251445