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  4. Recombinant Mouse Growth arrest and DNA damage-inducible proteins-interacting protein 1 (Gadd45gip1)

Recombinant Mouse Growth arrest and DNA damage-inducible proteins-interacting protein 1 (Gadd45gip1)

  • 中文名称：
    小鼠Gadd45gip1重组蛋白
  • 货号：
    CSB-YP866602MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gadd45gip1重组蛋白
  • 货号：
    CSB-EP866602MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gadd45gip1重组蛋白
  • 货号：
    CSB-EP866602MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gadd45gip1重组蛋白
  • 货号：
    CSB-BP866602MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gadd45gip1重组蛋白
  • 货号：
    CSB-MP866602MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gadd45gip1
  • Uniprot No.：
  • 别名：
    Gadd45gip1; Mrpl59; Growth arrest and DNA damage-inducible proteins-interacting protein 1; 39S ribosomal protein L59; mitochondrial; MRP-L59
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-222
  • 氨基酸序列
    MAALAMRSGY LLRLSVALGP RSRSYRAPPP PRRRPGPHSP DPENLLTPRW QLTPRYVAKQ FGRHGAISGV PPASLWPTPE QLRELEAEEQ EWYPSLATMQ ESLRLQQQAL EARRQAREQR IAECMAKMPQ MIENWRKQKR ERWEKIQADK ERRARLQAEA QERLGYHVDP RSARFQELLQ DLDKQQRKRL KEERQRQKKE ARIAAMASAE AQDSAVSGEP SS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
  • 基因功能参考文献：
    1. Crif1(beta-/-) mouse is a useful model for the study of beta cell failure caused by mitochondrial OxPhos dysfunction. PMID: 25660120
    2. The results identify the ROS-Sp1-Crif1 pathway to be a new mechanism underlying Abeta-induced mitochondrial dysfunction and suggest that ROS-mediated downregulation of Crif1 is a crucial event in AD pathology. PMID: 25361083
    3. CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc PMID: 24906005
    4. Study showed that loss of Crif1 impairs mitochondrial oxidative phosphorylation and adipocyte differentiation in vitro and in vivo. PMID: 23456335
    5. Crif1 plays a critical role in the maintenance of both mitochondrial structure and respiration in cardiac muscles. PMID: 23308255
    6. Although adipose-specific Crif1-haploinsufficient mice showed normal growth and development, they became insulin-resistant. PMID: 23516375
    7. CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane. PMID: 22819524
    8. Results reveal that Crif1 is a novel and essential transcriptional coactivator of Elf3 for the terminal differentiation of absorptive enterocytes. PMID: 19801644
    9. Crif1 is a novel and essential transcriptional coactivator of STAT3 that modulates its DNA binding ability. PMID: 18200042

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  • 亚细胞定位：
    Mitochondrion. Nucleus.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mL64 family
  • 数据库链接：

    KEGG: mmu:102060

    STRING: 10090.ENSMUSP00000037783

    UniGene: Mm.489649