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  4. Recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1galt1), partial

Recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1galt1), partial

  • 中文名称：
    Recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1(C1galt1),partial,Yeast
  • 货号：
    CSB-YP881314MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1(C1galt1),partial,Yeast
  • 货号：
    CSB-EP881314MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1(C1galt1),partial,Yeast
  • 货号：
    CSB-EP881314MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1(C1galt1),partial,Yeast
  • 货号：
    CSB-BP881314MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1(C1galt1),partial,Yeast
  • 货号：
    CSB-MP881314MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C1galt1
  • Uniprot No.：
  • 别名：
    C1galt1; Plt1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; EC 2.4.1.122; Core 1 O-glycan T-synthase; T-syn; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Core 1 beta1,3-galactosyltransferase 1; C1GalT1; Core 1 beta3-Gal-T1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
  • 基因功能参考文献：
    1. pancreas-specific conditional KO of C1galt1 expression of truncated O-glycans, which in turn accelerates Pancreatic ductal adenocarcinomas (PDACs) progression and metastasis. PMID: 30086262
    2. hepatic asialoglycoprotein receptor promotes preferential adherence to and phagocytosis of desialylated and/or HC C1galt1(-/-) platelets by the Kupffer cell through its C-type lectin receptor CLEC4F. These findings provide insights into an essential role for core 1 O-glycosylation of platelets in their clearance in the liver. PMID: 28716912
    3. Deletion of C1galt1 in mice develop spontaneous microbiota-dependent colitis with a remitting/relapsing course due to loss of mucin core-1 derived O-glycans. PMID: 27874308
    4. C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity. PMID: 25089569
    5. O-glycan is required for terminal megakaryocyte differentiation and platelet production and the decrease in GPIbalpha in cells lacking O-glycan might be caused by increased proteolysis. PMID: 23794065
    6. Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; C1galt1 and MGAT1 are required for embryo development and implantation. PMID: 22919046
    7. disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology PMID: 17062753
    8. It was found that targeted disruption of this gene causes embryonic lethality and defective angiogenesis in mice. PMID: 17113876
    9. Transgenic mice were generated lacking T-synthase (C1galt1). PMID: 18924607

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 31 family, Beta3-Gal-T subfamily
  • 组织特异性：
    Primarily expressed in endothelial, hematopoietic and epithelial cells during development.
  • 数据库链接：

    KEGG: mmu:94192

    STRING: 10090.ENSMUSP00000047931

    UniGene: Mm.102752