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  4. Recombinant Mouse Glutathione peroxidase 3 (Gpx3)

Recombinant Mouse Glutathione peroxidase 3 (Gpx3)

  • 中文名称：
    小鼠Gpx3重组蛋白
  • 货号：
    CSB-YP009868MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gpx3重组蛋白
  • 货号：
    CSB-EP009868MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gpx3重组蛋白
  • 货号：
    CSB-EP009868MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gpx3重组蛋白
  • 货号：
    CSB-BP009868MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gpx3重组蛋白
  • 货号：
    CSB-MP009868MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gpx3Glutathione peroxidase 3; GPx-3; GSHPx-3; EC 1.11.1.9; Plasma glutathione peroxidase; GPx-P; GSHPx-P
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-226
  • 氨基酸序列
    QEKSKT DCHGGMSGTI YEYGALTIDG EEYIPFKQYA GKYILFVNVA SYUGLTDQYL ELNALQEELG PFGLVILGFP SNQFGKQEPG ENSEILPSLK YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTA ELLGSPGRLF WEPMKIHDIR WNFEKFLVGP DGIPVMRWYH RTTVSNVKMD ILSYMRRQAA LSARGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
  • 基因功能参考文献：
    1. the antioxidant enzyme GPX3 localizes to lung extracellular matrix and is variably upregulated in interstitial lung diseases. PMID: 27435875
    2. These results suggest that GPx3 is an important factor for inhibition of Acetaminopheninduced hepatotoxicity both in vivo and in vitro. PMID: 28677736
    3. GPX3 promoter methylation predicts colorectal carcinoma sensitivity to platinum. PMID: 27918237
    4. Results indicate that selenoprotein P (Sepp1) is important for this transport in selenium-replete mice but that glutathione peroxidase-3 (Gpx3) is not. PMID: 25068390
    5. GPx3 may have a possible role in modulating prostate carcinogenesis. PMID: 21374652
    6. Sepp1(UF) and small selenium-containing proteins are filtered by the glomerulus and taken up by PCT cells via megalin-mediated endocytosis, preventing loss of selenium in the urine and providing selenium for the synthesis of glutathione peroxidase-3 PMID: 24434121
    7. GPX3 may play a major role in reducing hydrogen peroxide during decidualization. PMID: 24631040
    8. an immunomodulatory role for GPX3 that limits the development of colitis-associated carcinoma. PMID: 23221387
    9. We applied X-ray fluorescence microscopy to image selenium in mammalian tissues and identified a highly localized pool of this trace element at the basement membrane of kidneys that was associated with GPx3 PMID: 21854231
    10. These results show that glutathione peroxidase 3 from the blood binds to basement membranes of specific epithelial cells and indicate that the cells modify their basement membranes to cause the binding. PMID: 21493731
    11. GPx-3 deficiency results in a prothrombotic state and vascular dysfunction that promotes platelet-dependent arterial thrombosis PMID: 21518981
    12. Inflammatory injury in the intestine elicits an increase in E-GPx in the plasma that is associated with an increase in E-GPx mRNA in the kidney. This implies that renal production of E-GPx may be sensitive to insults distal to the kidney. PMID: 11978890
    13. The expression of Gpx3 decreased at the aortic sinus in a murine model of high-fat diet-induced atherogenesis. PMID: 16508038
    14. GPX-3 may play a significant role in protecting cardiomyocytes from oxidative stress caused by hyperglycemia PMID: 16651743
    15. This is the first report that a particular isotype of the glutathione peroxidase family is regulated by TCDD at both mRNA and protein levels PMID: 16682824
    16. c-maf may be transcriptional regulator of GPx3 expression and modulate the antioxidative pathway in the kidney PMID: 16890189
    17. GPx3 expression was reduced selectively in the adipose tissue of several obese animal models as decreasing plasma GPx3 level. PMID: 18562625

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glutathione peroxidase family
  • 组织特异性：
    Secreted in plasma.
  • 数据库链接：

    KEGG: mmu:14778

    STRING: 10090.ENSMUSP00000081011

    UniGene: Mm.200916