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  4. Recombinant Mouse Glutathione S-transferase P 2 (Gstp2)

Recombinant Mouse Glutathione S-transferase P 2 (Gstp2)

  • 货号：
    CSB-YP344378MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP344378MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP344378MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP344378MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP344378MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gstp2
  • Uniprot No.：
  • 别名：
    Gstp2; Gstpia; Glutathione S-transferase P 2; Gst P2; EC 2.5.1.18; GST YF-YF; GST class-pi; GST-piA
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-210
  • 氨基酸序列
    PPYTIVYFP SPGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKNQREAAQV DMVNDGVEDL RGKYGTMIYR NYENGKNDYV KALPGHLKPF ETLLSQNQGG KAFIVGDQIS FADYNLLDLL LIHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPEHV NRPINGNGKQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.
  • 基因功能参考文献：
    1. GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration. PMID: 25590808
    2. Apc(Min/+)Gstp1/p2(-/-) (Gstp-null Apc(Min)) mice had a 6-fold increase in colon adenoma incidence, and a 50-fold increase in colorectal adenoma multiplicity, relative to Gstp-wt Apc(Min). PMID: 19915149
    3. Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells. PMID: 11895860
    4. critical role of allyl groups and disulfide chain in induction by diallyl disulfide, a naturally occurring chemopreventive agent in garlic PMID: 12376475
    5. role as a direct inhibitor of JNK in vivo and in regulating the constitutive expression of specific downstream molecular targets of the JNK signaling pathway PMID: 12646564
    6. These results suggest that GSTpi may play a protective role in the development of spontaneous tumors. PMID: 15386426
    7. The glutathione S-transferase, pi 2 was represented by two EST clones with similar levels of downregulation. PMID: 15629866
    8. The downregulation of Gstp2 may induce an increase of oxidative damage in the pyramidal cells of the CA1 and CA3 regions and granular layer of the dentate gyrus, leading to structural and functional damage. PMID: 16643866
    9. GSTP protects against the endothelial dysfunction induced by tobacco smoke exposure and that this protection may be related to the detoxification of acrolein or other related cigarette smoke constituents. PMID: 19270193

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  • 蛋白家族：
    GST superfamily, Pi family
  • 组织特异性：
    Selectively expressed in gall bladder, colon, heart, and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:14869

    STRING: 10090.ENSMUSP00000038931

    UniGene: Mm.441542