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  4. Recombinant Mouse Glucose-6-phosphatase (G6pc), partial

Recombinant Mouse Glucose-6-phosphatase (G6pc), partial

  • 中文名称：
    小鼠G6pc重组蛋白
  • 货号：
    CSB-YP009118MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠G6pc重组蛋白
  • 货号：
    CSB-EP009118MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠G6pc重组蛋白
  • 货号：
    CSB-EP009118MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠G6pc重组蛋白
  • 货号：
    CSB-BP009118MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠G6pc重组蛋白
  • 货号：
    CSB-MP009118MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    G6pc; G6pt; Glucose-6-phosphatase; G-6-Pase; G6Pase; EC 3.1.3.9
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
  • 基因功能参考文献：
    1. Hepatic mitochondrial dysfunction is a feature of glycogen storage disease type Ia with glucose-6-phosphatase deficiency. PMID: 28317891
    2. hepatic G6Pase-alpha deficiency causes metabolic reprogramming, leading to enhanced glycolysis and elevated hexose monophosphate shunt that along with impaired autophagy can contribute to hepatocellular adenoma/carcinoma development in glycogen storage disease type Ia. PMID: 29545180
    3. We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad. PMID: 28749080
    4. Data show that glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in notch1 knockout (KO) mice. PMID: 27428080
    5. We conclude that G6PD deficiency at the level of the animals in the present study may not be a risk factor for developing CSN-OT, but this remains to be verified for human subjects PMID: 22075642
    6. The results strongly suggested that the increase of glucagon levels could account for the induction of G6pc expression in the kidneys and intestine of L-G6pc-/- mice. PMID: 22013018
    7. PPARalpha is responsible for glucose production through the up-regulation of hepatic G6Pase gene expression during fasting or type 2 diabetes animal models PMID: 21081500
    8. gene transcription in H4IIE cells mediated by hepatocyte nuclear factor-4 alpha's stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha PMID: 12416993
    9. Evidence for the expression of the catalytic domain of hepatic glucose-6-phosphatase in pancreatic islets. PMID: 12878201
    10. Loss of G6pt activity causes neutropenia, and local production of the chemokines KC and macrophage inflammatory protein-2 are defective in G6pt-/- neutrophils. PMID: 12925567
    11. G6pc expression was functionally silenced by adenovirus-mediated delivery of short hairpin RNA. PMID: 14759518
    12. muscle expresses both Glc-6-Pase-beta and Glc-6-P transporter and that they can couple to form an active Glc-6-Pase complex PMID: 15087461
    13. Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production. PMID: 15661744
    14. Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase PMID: 17203215
    15. HNF-4 and Foxo1 are required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding PMID: 18805788
    16. EGF also inhibits hepatic G6Pase gene expression in vivo PMID: 18847435
    17. study identified SRC-2 as a regulator of fasting hepatic glucose release, a function that SRC-2 performs by controlling expression of hepatic G6Pase; SRC-2 modulates G6Pase expression by acting as a coactivator with the orphan nuclear receptor RORalpha PMID: 19039140

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glucose-6-phosphatase family
  • 组织特异性：
    Liver and kidney.
  • 数据库链接：

    KEGG: mmu:14377

    STRING: 10090.ENSMUSP00000019469

    UniGene: Mm.18064