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  4. Recombinant Mouse Geminin coiled-coil domain-containing protein 1 (Gmnc)

Recombinant Mouse Geminin coiled-coil domain-containing protein 1 (Gmnc)

  • 中文名称：
    小鼠Gmnc重组蛋白
  • 货号：
    CSB-YP662387MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gmnc重组蛋白
  • 货号：
    CSB-EP662387MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gmnc重组蛋白
  • 货号：
    CSB-EP662387MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gmnc重组蛋白
  • 货号：
    CSB-BP662387MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gmnc重组蛋白
  • 货号：
    CSB-MP662387MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gmnc
  • Uniprot No.：
  • 别名：
    Gmnc; Gemc1; Gm606Geminin coiled-coil domain-containing protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-333
  • 氨基酸序列
    MNSILPCQDQ YFVGGQSYNC PYSTTTSESG VDVSKETWVS FWAAGLLDNT ELQQAPQVLE SPSELSFPVL DSCSWEEAQL SSQLYRNKQL QDTLLQKEEE LARLHEENNH LRQYLNSTLV KRLEEKAKKL LSSDEFSKVF GKLRKEKRKP KEHRHSPAEI PQFKTAKRNL STEFSNCEEQ PGPHVDPWVL QTLGLKDLNT IDDTLPANYS ATTSHPRAVP SISSLFVHDA NGYANVPRDL HLDYVGQGTH GSHTTSIHQE DCHSFPRLSN PPVRVQTLPY HTADVSPNKT EMAFSTSLSP HCNVKTHSFH QGQAFVRRDE EGGWKFTWVP KQT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins.
  • 基因功能参考文献：
    1. The s found that GEMC1-deficient mice are growth impaired, develop hydrocephaly with a high penetrance, and are infertile, due to defects in the formation of multiciliated cells in the brain, respiratory tract, and germline. PMID: 26933123
    2. GemC1 directly transactivates the promoters of MCIDAS and FOXJ1. PMID: 26882546
    3. Results suggest that Mcidas and GemC1 are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche. PMID: 26395491
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    GEMC1 family
  • 数据库链接：

    KEGG: mmu:239789

    STRING: 10090.ENSMUSP00000087269

    UniGene: Mm.326909