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  4. Recombinant Mouse Gamma-aminobutyric acid receptor subunit delta (Gabrd), partial

Recombinant Mouse Gamma-aminobutyric acid receptor subunit delta (Gabrd), partial

  • 中文名称：
    小鼠Gabrd重组蛋白
  • 货号：
    CSB-YP009149MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gabrd重组蛋白
  • 货号：
    CSB-EP009149MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gabrd重组蛋白
  • 货号：
    CSB-EP009149MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gabrd重组蛋白
  • 货号：
    CSB-BP009149MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gabrd重组蛋白
  • 货号：
    CSB-MP009149MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabrd
  • Uniprot No.：
  • 别名：
    Gabrd; Gamma-aminobutyric acid receptor subunit delta; GABA(A) receptor subunit delta
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能参考文献：
    1. Using mice with or without deletion of GABRD and protocols in which the conditioned tone stimuli were cross presented with different nonconditioned stimuli, study showed that when the 2 tone stimuli were largely similar, both genotypes froze similarly to either of them. However, when they differed markedly, the knockout mice froze much more than their wild-type littermates to the nonconditioned but not conditioned stimuli PMID: 28716958
    2. findings suggest that GABAA(delta)R serves as a brake rather than a mediator of GABAergic inhibition in Lateral Amygdala. PMID: 27591789
    3. Reduced GABAA R delta subunit expression and function in dentate gyrus granule cells is sufficient to induce deficits in learning and memory in mice. Findings suggest that the reduction in GABAA R delta subunit-mediated tonic inhibition in dentate gyrus granule cells contributes, at least in part, to deficits in learning and memory associated with chronic stress. PMID: 27163381
    4. GABA A receptors delta subunit are necessary for synaptic plasticity in the CA3 field of hippocampus and for memory behavior. PMID: 27464975
    5. This study demonstrated that Ectopic Expression of delta GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. PMID: 26658866
    6. Results show that delta-GABAARs expressed on parvalbumin interneurons modulate in vitro hippocampal gamma oscillations dynamics PMID: 25261782
    7. This study demonstrated that alpha6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells. PMID: 26134650
    8. Gabrd subunits are expressed in the extrasynaptic cell membrane of interneurons in the dentate gyrus. PMID: 24055402
    9. In an alpha4 subunit knockout mouse, a substantial decrease in delta subunit expression was seen in the ventrobasal nucleus of the thalamus. PMID: 24352815
    10. The delta-GABAAR plays an important role in estrous cycle-mediated fluctuations in hippocampus-dependent learning and memory. PMID: 24667980
    11. Perimenstrual neurosteroid withdrawal is associated with upregulation of Gabrd receptors that mediate tonic inhibition in the dentate gyrus. PMID: 25339733
    12. results show the importance of the GABAAR d subunit in the regulation of CRH neurons, and the HPA axis, and demonstrate that dysregulation of CRH neurons alters stress-related behaviors. PMID: 24495609
    13. This glutamate neuroplasticity was not observed in GABAA receptor delta-subunit-knockout (delta-KO) mice. PMID: 24077066
    14. The results of this study deltaGABAA receptors promote the performance of certain DG-dependent memory behaviors and facilitate neurogenesis. Furthermore, deltaGABAA receptors can be pharmacologically targeted to enhance these processes. PMID: 23686887
    15. Data suggest that estrous cycle-related regulation of neurosteroid-sensitive delta subunit-containing GABA(A) receptors mediates neuronal inhibition/plasticity and seizure susceptibility; delta subunit is upregulated in dentate gyrus during diestrus. PMID: 23667248
    16. GABAA delta-subunit-containing receptors are not required for enhancement of excitability and conduction velocity of cerebellar parallel fiber axons, since GABA facilitates both spike generation and propagation. PMID: 22378171
    17. In both native and heterologous recombinant systems, murine delta subunit incorporation into GABARs leads to a dramatic increase in THIP sensitivity, a defining feature that accounts for the unique behavioral and neurophysiological properties of THIP. PMID: 21795619
    18. The results of this study suggested that deltaGABA(A)Rs in spinal neurons play a major physiological and pharmacological role in the regulation of acute nociception and central sensitization. PMID: 21396779
    19. Data indicate that slow outward currents in thalamocortical neurons arise from astrocytic GABA release, and are mediated by delta-subunit-containing GABA(A) receptors. PMID: 21395866
    20. Ambient GABA and synaptic spillover are sensed by distinct GABAAR populations. PMID: 21228184
    21. GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons PMID: 12367609
    22. although the delta subunit confers a striking PS insensitivity to eIPSCs in ventral basal complex neurons, it plays only a minor role in the synaptic inhibition of these neurons. PMID: 12626617
    23. Decreased synaptic and extrasynaptic inhibition likely contributes to the pro-epileptic phenotype of delta-mutants. PMID: 12702713
    24. Our results demonstrate a perisynaptic localization of delta subunit-containing GABA(A) receptors and indicate that these receptors can be activated by GABA overspill in the molecular layer PMID: 14627650
    25. A significant decrease in tonic inhibition occurs in pregnant mice, mediated by a downregulation of GABA(A) receptor delta subunit, which rebounds immediately postpartum. PMID: 18667149
    26. alterations in GABAAR expression during pregnancy result in brain region-specific increases in neuronal excitability that are restored by the high levels of allopregnanolone under normal conditions PMID: 19641122

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRD sub-subfamily
  • 数据库链接：

    KEGG: mmu:14403

    STRING: 10090.ENSMUSP00000030925

    UniGene: Mm.388925