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  4. Recombinant Mouse Gamma-aminobutyric acid receptor subunit beta-2 (Gabrb2), partial

Recombinant Mouse Gamma-aminobutyric acid receptor subunit beta-2 (Gabrb2), partial

  • 中文名称：
    小鼠Gabrb2重组蛋白
  • 货号：
    CSB-YP009147MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gabrb2重组蛋白
  • 货号：
    CSB-EP009147MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gabrb2重组蛋白
  • 货号：
    CSB-EP009147MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gabrb2重组蛋白
  • 货号：
    CSB-BP009147MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gabrb2重组蛋白
  • 货号：
    CSB-MP009147MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabrb2
  • Uniprot No.：
  • 别名：
    Gabrb2; Gabrb-2Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.
  • 基因功能参考文献：
    1. Rebound potentiation is an input-specific plasticity that occurs only at basket cell-Purkinje cell inhibitory synapses and critically relies on GABAA receptors containing the beta2-subunit. PMID: 26179122
    2. Gabrb2 receptor subunits are expressed in interneurons of the dentate gyrus along with alpha1 and delta subunits. PMID: 24055402
    3. The gamma2 subunits (of GABA A receptors) interacted with Beta2 subunit N-glycans and subdomains containing the glycosylation sites. PMID: 24213971
    4. In an epileptic stargazer mouse model, Gabrb2 receptor subunit expression in the ventral thalamus is increased. PMID: 24417662
    5. These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops. PMID: 23205938
    6. Data indicate that the expression levels of [beta]2/3 GABAAR showed 2.81 +/- 0.08-fold and 3.83 +/- 0.07-fold increases, respectively, in the pancreatectomized mice 3 and 14 days after surgery. PMID: 23486367
    7. deletion of beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs PMID: 12490572
    8. GABA(A) receptors interact directly with ethylmaleimide sensitive factor, a critical regulator of vesicular dependent protein trafficking. PMID: 16095914
    9. Deletion of the beta(2) subunit had no effect on the diazepam-induced current and therefore these extrasynaptic receptors do not contain this subunit. PMID: 18079158
    10. Different NMDA-receptor subunit 1 and GABA(B)-receptor subunit 2 levels observed in naive mouse strains reflect strain-dependent expression of subunits and are proposed to lead to altered stoichiometry of GABA(B)-receptor complexes. PMID: 19524116

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB2 sub-subfamily
  • 数据库链接：

    KEGG: mmu:14401

    UniGene: Mm.338723