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  4. Recombinant Mouse Gamma-aminobutyric acid receptor subunit alpha-4 (Gabra4), partial

Recombinant Mouse Gamma-aminobutyric acid receptor subunit alpha-4 (Gabra4), partial

  • 中文名称：
    小鼠Gabra4重组蛋白
  • 货号：
    CSB-YP887532MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gabra4重组蛋白
  • 货号：
    CSB-EP887532MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gabra4重组蛋白
  • 货号：
    CSB-EP887532MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gabra4重组蛋白
  • 货号：
    CSB-BP887532MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gabra4重组蛋白
  • 货号：
    CSB-MP887532MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabra4
  • Uniprot No.：
  • 别名：
    Gabra4Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能参考文献：
    1. These data suggest that pubertal synaptic pruning requires alpha4betadelta GABA-A receptors. PMID: 27136678
    2. Gabra4 KO CD4(+) cells produced increased cytokines. PMID: 28473323
    3. Rindings suggest that knock-out of the GABAR alpha4 subunit restores synaptic plasticity and spatial learning at puberty and is consistent with the concept that the dendritic alpha4betadelta GABARs which emerge at puberty selectively impair central nervous system plasticity. PMID: 26826007
    4. This study addressed the effects of AW on changes in the expression of Gabra4 and related genes that encode other subunits of GABAARs PMID: 26357588
    5. The alpha4 subunit-containing GABA A-receptors are required for the low dose, locomotor stimulatory effect of anesthetics. PMID: 24062179
    6. GABAA receptors in the mediodorsal thalamic nucleus (MD) modulate fear extinction. PMID: 24886120
    7. Increase in GABRA4 activity promotes hippocampal neurogenesis via nuclear factor of activated T cell (NFATc)4. PMID: 24948817
    8. This study demonistrated that alpha4-GABAARs contribute to nRT burst-mediated inhibition and that activity-dependent recruitment of eGABAARs dynamically influences the ventrobasal neuron tonic conductance during nRT tonic spike trains. PMID: 24027285
    9. alpha4 subunit expression strongly influences the pubertal increase of delta subunits at the plasma membrane, and that genetic deletion of alpha4 serves as a functional knock-down of delta-containing GABARs. PMID: 22418059
    10. findings show that emergence of alpha4betadelta GABARs at puberty impairs learning, an effect that can be reversed by a stress steroid PMID: 20299596
    11. alpha-4 subunit of the GABAA receptor is transcriptionally regulated PMID: 15265862
    12. Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. PMID: 19923508

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA4 sub-subfamily
  • 数据库链接：

    KEGG: mmu:14397

    STRING: 10090.ENSMUSP00000031121

    UniGene: Mm.248731