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  4. Recombinant Mouse GTP-binding protein GEM (Gem)

Recombinant Mouse GTP-binding protein GEM (Gem)

  • 中文名称：
    小鼠Gem重组蛋白
  • 货号：
    CSB-YP009362MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gem重组蛋白
  • 货号：
    CSB-EP009362MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gem重组蛋白
  • 货号：
    CSB-EP009362MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gem重组蛋白
  • 货号：
    CSB-BP009362MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gem重组蛋白
  • 货号：
    CSB-MP009362MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gem
  • Uniprot No.：
  • 别名：
    Gem; KirGTP-binding protein GEM; GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-295
  • 氨基酸序列
    MTLNNVTMRQ GTVGMQPQQR WSIPADARHL MVQKDPHPCN LRNRHSTAPE EHCRRSWSSD STDSVISSES GNTYYRVVLI GEQGVGKSTL ANIFAGVHDS MDSDCEVLGE DTYERTLVVD GESATIILLD MWENKGENEW LHDHCMQVGD AYLIVYSITD RASFEKASEL RIQLRRARQT EDIPIILVGN KSDLVRCREV SVSEGRACAV VFDCKFIETS AAVQHNVKEL FEGIVRQVRL RRDSKEKNER RLAYQKRRES IPRKARRFWG KIVAKNNKNM AFKLKSKSCH DLSVL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
  • 基因功能参考文献：
    1. Rad, Gem and Rem all reduce depolarization-dependent Ca2+ entry in developing myotubes. PMID: 24476902
    2. These results suggest that Gem plays an important role in normal beta-cell function by regulation of calcium signalling. PMID: 22761801
    3. Mechanism of the inhibition of calcium channel activity by Gem. PMID: 15615719
    4. docking of the RGK protein to the nucleotide-kinase domain of the Cavbeta subunit is reminiscent of the binding of GMP to guanylate kinase PMID: 17303572
    5. Results identify specific nuclear localization signals (NLS) in Kir/Gem that are both required and sufficient for nuclear transport. PMID: 17605761
    6. protein expression regulation; calcium channel expression PMID: 11395774

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, RGK family
  • 数据库链接：

    KEGG: mmu:14579

    STRING: 10090.ENSMUSP00000029868

    UniGene: Mm.247486