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  4. Recombinant Mouse Friend of PRMT1 protein (Fop)

Recombinant Mouse Friend of PRMT1 protein (Fop)

  • 中文名称：
    Recombinant Mouse Friend of PRMT1 protein(Fop),Yeast
  • 货号：
    CSB-YP880446MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Friend of PRMT1 protein(Fop),Yeast
  • 货号：
    CSB-EP880446MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Friend of PRMT1 protein(Fop),Yeast
  • 货号：
    CSB-EP880446MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Friend of PRMT1 protein(Fop),Yeast
  • 货号：
    CSB-BP880446MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Friend of PRMT1 protein(Fop),Yeast
  • 货号：
    CSB-MP880446MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Chtop
  • Uniprot No.：
  • 别名：
    Chtop; Fop; MNCb-1706Chromatin target of PRMT1 protein; Friend of PRMT1 protein; Small arginine- and glycine-rich protein; SRAG
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-249
  • 氨基酸序列
    AAQSAPKVV LKSTTKMSLN ERFTNMLKNK QPMPVNIRAS MQQQQQLASA RNRRLAQQME NRPSVQAALK LKQKSLKQRL GKSNIQARLG RPIGALARGA IGGRGLPIIQ RGLPRGGLRG GRATRTLLRG GMSLRGQNLL RGGRAVAPRM GLRRGGVRGR GGPGRGGLGR GAMGRGGIGG RGRGMIGRGR GGFGGRGRGR GRGRGALTRP VLTKEQLDNQ LDAYMSKTKG HLDAELDAYM AQTDPETND
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis.
  • 基因功能参考文献：
    1. The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression. PMID: 20688955
    2. Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2). PMID: 19858291
  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle.
  • 组织特异性：
    Broadly expressed with highest levels found in thymus, spleen, and lymph nodes. Expressed in an erythroid progenitor cell line derived from fetal liver.
  • 数据库链接：

    KEGG: mmu:66511

    STRING: 10090.ENSMUSP00000001043

    UniGene: Mm.154136