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  4. Recombinant Mouse Forkhead box protein I1 (Foxi1)

Recombinant Mouse Forkhead box protein I1 (Foxi1)

  • 中文名称：
    小鼠Foxi1重组蛋白
  • 货号：
    CSB-YP849730MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Foxi1重组蛋白
  • 货号：
    CSB-EP849730MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Foxi1重组蛋白
  • 货号：
    CSB-EP849730MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Foxi1重组蛋白
  • 货号：
    CSB-BP849730MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Foxi1重组蛋白
  • 货号：
    CSB-MP849730MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxi1
  • Uniprot No.：
  • 别名：
    Foxi1Forkhead box protein I1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-372
  • 氨基酸序列
    MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG MPSPQRPTSF EGGGEYGTTP NPYLWLNGPA MTPPPYLPGT NASPFLPQAY GMQRQLLPSD LGWLPIPSQE ELMKLVRPPY SYSALIAMAI HGAPDQRLTL SQIYQYVADN FPFYNKSKAG WQNSIRHNLS LNDCFKKVPR DEDDPGKGNY WTLDPNCEKM FDNGNFRRKR KRKSDSSSST SSLASEKTEN GLLASSPKPT EPQEVLDTAS PDTTTSSPEK RSSPAPSGTP CLNNFLSTMT AYVSGTNPIS RSVATPGLSS EPIDKMGQNS LNFNSYTPLT NLSSHGNGGE WANPVATNAL GYGGSVFNQF SPHFYNSINT NGILFPREGT EV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules.
  • 基因功能参考文献：
    1. mutations in FOXI1 could prove to cause a Pendred syndrome-like human deafness PMID: 12642503
    2. examined the expression patterns of the Foxi class genes from embryonic day 6.5 to 10.5; Foxi1 expression is first detected in the endolymphatic duct in the otic vesicle at E10.5 PMID: 15376323
    3. The AE4 promoter is identified as a direct target of Foxi1. PMID: 16159312
    4. Spermatozoa from Foxi1 null males fail to reach the female genital tract in sufficient number to allow fertilization. PMID: 16932748
    5. Data suggestthat Foxi1 is necessary for expression of at least four subunits in three different epithelia and most likely is a major determinant for proper assembly of a functional vacuolar H(+)-ATPase complex at these locations. PMID: 19214237
    6. Foxa1 and Foxi1 are required for later stage sweat gland development. PMID: 19270025

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in intercalated cells of the epithelium of the distal renal tubule.
  • 数据库链接：

    KEGG: mmu:14233

    STRING: 10090.ENSMUSP00000058651

    UniGene: Mm.32926