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  4. Recombinant Mouse Fibroblast growth factor 14 (Fgf14)

Recombinant Mouse Fibroblast growth factor 14 (Fgf14)

  • 中文名称：
    小鼠Fgf14重组蛋白
  • 货号：
    CSB-YP008620MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fgf14重组蛋白
  • 货号：
    CSB-EP008620MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fgf14重组蛋白
  • 货号：
    CSB-EP008620MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fgf14重组蛋白
  • 货号：
    CSB-BP008620MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fgf14重组蛋白
  • 货号：
    CSB-MP008620MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fgf14
  • Uniprot No.：
  • 别名：
    Fgf14; Fhf4Fibroblast growth factor 14; FGF-14; Fibroblast growth factor homologous factor 4; FHF-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-247
  • 氨基酸序列
    MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLF NGNLVDIFSK VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ VMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP VNKCKTT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probably involved in nervous system development and function.
  • 基因功能参考文献：
    1. These new insights into the biology of FGF14 in neurogenesis shed light into the signaling pathways associated with disrupted functions in complex brain diseases. PMID: 26687232
    2. These results indicate that Fgf14(-/-) mice recapitulate salient molecular, cellular, functional and behavioral features associated with human cognitive impairment, and FGF14 loss of function might be associated with the biology of complex brain disorders such as schizophrenia. PMID: 27163207
    3. TWEAK/Fn14 pathway instrumental in the pathogenesis of spontaneous lupus nephritis PMID: 25270074
    4. The results of this study demonstrated that iFGF14 is required for spontaneous and evoked action potential firing in adult Purkinje neurons, thereby controlling the output of these cells and the regulation of motor coordination and balance. PMID: 25926453
    5. These data suggest that the FGF14b N-terminus is a potent regulator of resurgent NaV current in cerebellar Purkinje neurons. PMID: 25269146
    6. FGF14 is localized in a decreasing proximal to distal gradient along the axon initial segment of Purkinje neurons. PMID: 23891806
    7. FGF14 regulates presynaptic Ca2+ channels and synaptic transmission in cultured rat neurons. PMID: 23831029
    8. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons. PMID: 23640885
    9. Fgf14-deficient mice developed ataxia and a paroxysmal hyperkinetic movement disorder. FGF14 may mediate neuronal signaling, axonal trafficking and synaptosomal function. PMID: 12123606
    10. FGF14 in regulating synaptic plasticity via presynaptic mechanisms by affecting the mobilization, trafficking, or docking of synaptic vesicles to presynaptic active zones. PMID: 17208450
    11. these results suggest a role for FGF14 in certain spatial learning functions and synaptic plasticity PMID: 17236779
    12. Sodium channels in Fhf1-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state. PMID: 17678857
    13. results suggest that FGF14 is required for normal Nav1.6 expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 channels PMID: 18930825

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 组织特异性：
    Brain and testis; widely distributed in the developing nervous system. In adult, high levels in the granular layer of the cerebellum, less in hippocampus and olfactory bulb.
  • 数据库链接：

    KEGG: mmu:14169

    STRING: 10090.ENSMUSP00000093185

    UniGene: Mm.206362