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  4. Recombinant Mouse Fasciculation and elongation protein zeta-1 (Fez1)

Recombinant Mouse Fasciculation and elongation protein zeta-1 (Fez1)

  • 货号：
    CSB-YP812962MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP812962MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP812962MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP812962MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP812962MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fez1
  • Uniprot No.：
  • 别名：
    Fez1Fasciculation and elongation protein zeta-1; Zygin I; Zygin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-392
  • 氨基酸序列
    MEAPLVSLDE EFEDIRPSCT EEPEEKPQCL YGTSPHHLED PSLSELENFS SEIISFKSME DLVNEFDEKL NVCFRNYNAK TESLAPVKNQ LQIQEEEETL RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDIEIHE KEEEEFNEKS ENDSGINEEP LLTADQVIEE IEEMMQNSPD PEEEEEVLEE EDGGEISSQA DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDRVE GAIRDFSEEL VHQLARRDEL EFEKEVKNSF ITVLIEVQNK QREQRELMKK RRKEKGLSLQ SNRIEKGSQM PLKRFSMEGI SNILQSGIRQ TFGSSGADRQ YLNTVIPYEK KSSPPSVEDL QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.
  • 基因功能参考文献：
    1. Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking. PMID: 27247180
    2. Dendrite growth depends on degradation of FEZ1 regulated by Cdc20/APC. PMID: 24726361
    3. Fezzeta-1 interacts with disrupted in schizophrenia (DISC)1 to synergistically regulate dendritic growth of newborn neurons in the adult mouse hippocampus. PMID: 22099459
    4. Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex. PMID: 15579145
    5. investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1 PMID: 18647754

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane.
  • 蛋白家族：
    Zygin family
  • 数据库链接：

    KEGG: mmu:235180

    STRING: 10090.ENSMUSP00000034630

    UniGene: Mm.5264