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  4. Recombinant Mouse Fanconi anemia group C protein homolog (Fancc)

Recombinant Mouse Fanconi anemia group C protein homolog (Fancc)

  • 中文名称：
    小鼠Fancc重组蛋白
  • 货号：
    CSB-YP008415MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fancc重组蛋白
  • 货号：
    CSB-EP008415MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fancc重组蛋白
  • 货号：
    CSB-EP008415MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fancc重组蛋白
  • 货号：
    CSB-BP008415MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fancc重组蛋白
  • 货号：
    CSB-MP008415MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fancc
  • Uniprot No.：
  • 别名：
    Fancc; Fac; FaccFanconi anemia group C protein homolog; Protein FACC
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-591
  • 氨基酸序列
    MAQESADLAS DCQSWLQKLS AWEQASSEET QKDTCLHLSG FQEFLRQMYE ILKEMDSDAI LERFPTIGQL LAKACWNPLI LAYDESQKIV IWCLCCLMNK EPRTSAESGL NSWIRGLLSH VLSAFRFDMK EVCLFTKSLG YESIDYYPSL LKNMVLSLVS ELRESHLNGL STQSRMAPER MMSLSEVCVP LVTLPDMEPL VEALLTYHGH EPQEVLAPEF FEAVNEAFLS EKIVLPTSSV VSLWFRHLPS LEKATLHLFE KLFSSKIICL RRMECCIRES FLPQAACQPA IFRIVDEMFR FVLLETDGAP EVLAALQVFT SCLVEALKKE NKQLTFALRT YFPYGAPCLA AALSQHPEAI PQGHRLQPLL HISQLLREAV EDCTRGSPRN PFESWFLFVH FGGWVDLAVA ELLLREEAEP PAGLLWLLVF YYSPQDGSQQ REQSMVELKV LINRLLMLLR SGPLSATDLQ EAAESPSGDP RPPVCGQLVR RLLLSLLLWT PEGHAIVWEA VTHGPTFEIT GPGCCPRIWR STRPQHRPRA HLCCTEMAHT DAVIHEIIGF LDQTLYRSQH LCVEASRKLA RDLLKELQAQ V
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
  • 基因功能参考文献：
    1. Genetic deletion of Fancc blocks the autophagic clearance of viruses (virophagy) and increases susceptibility to lethal viral encephalitis. Fanconi anemia complementation group C (FANCC) protein interacts with Parkin, is required in vitro and in vivo for clearance of damaged mitochondria, and decreases mitochondrial reactive oxygen species (ROS) production and inflammasome activation. PMID: 27133164
    2. Data show that Fanconi anemia, complementation group C protein knockout (Fancc -/-) mice develop hematopoietic chromosomal instability followed by leukemia in an age-dependent manner. PMID: 26860989
    3. Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway PMID: 26895835
    4. Combined deficiency of Foxo3a and Fancc or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis. PMID: 24483844
    5. Using mice deficient in both Mus81 and the FA pathway protein FancC, we show both proteins cooperate in parallel pathways, as concomitant loss of FancC and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero. PMID: 25056314
    6. Loss of FANCC leads to a drastic increase in stalled/collapsed forks in cells carrying an Mcm4 missense mutation. PMID: 24589582
    7. FANCC is most likely to be critical for resistance to DNA cross-linking drug-induced DNA damage in cells transformed by JAK2 V617F mutant. PMID: 23838005
    8. Data indicate that IL-1beta overproduction from FANCC-deficient macrophages is p38 dependent. PMID: 24046015
    9. Loss of FANCC expression results in an impaired emergency granulopoiesis response in a transgenic mouse model of Fanconi anemia. PMID: 23925293
    10. Compromised hematopoiesis in Fancc(-/-) animals is developmentally programmed and does not arise de novo in bone marrow. PMID: 23315168
    11. Double-mutant Fancc(-/-);Fancg(-/-) mice develop spontaneous hematologic sequelae including bone marrow failure, acute myeloid leukemia, myelodysplasia and complex random chromosomal abnormalities that the single-mutant mice do not. PMID: 20606166
    12. Fancc deficiency accelerates telomere shortening during high turnover of hematopoietic cells and promotes telomere recombination initiated by short telomeres. PMID: 20022886
    13. whereas Fancc-/- mice failed to form hematopoietic or solid malignancies, mice mutant at both Fancc and Trp53 developed tumors more rapidly than mice mutant at Trp53 alone. PMID: 12855557
    14. Fancc mutations result in a subtle immunological defect owing to the failure of FANCC to normally support Janus kinase/STAT signaling, such that differentiation of Fancc-/- CD4+ T cells into the Th1 subset is impaired in Fancc-deficient mice. PMID: 15356134
    15. the intrinsic defects in the genomic stability of Fancc(-/-) stem/progenitor cells provide a selective pressure for cells that are resistant to apoptosis and have a propensity for the evolution to clonal hematopoiesis and malignancy PMID: 15644418
    16. predisposition of Fancc-/- hematopoietic progenitors to apoptosis is mediated in part through altered redox regulation and apoptosis signal-regulating kinase 1 hyperactivation PMID: 16109778
    17. Data suggest that TNF-alpha exposure creates an environment in which somatically mutated preleukemic stem cell clones are selected and from which unaltered TNF-alpha-hypersensitive Fancc-/- stem cells are purged. PMID: 17960249
    18. Short-term transduction of c-kit(+) cells with a foamyviral vector is sufficient for functional correction of a stem cell phenotype in a murine Fanconi anemia model. PMID: 18684868

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:14088

    UniGene: Mm.126106