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  4. Recombinant Mouse Endothelin-3 (Edn3)

Recombinant Mouse Endothelin-3 (Edn3)

  • 中文名称：
    小鼠Edn3重组蛋白
  • 货号：
    CSB-YP007402MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Edn3重组蛋白
  • 货号：
    CSB-EP007402MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Edn3重组蛋白
  • 货号：
    CSB-EP007402MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Edn3重组蛋白
  • 货号：
    CSB-BP007402MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Edn3重组蛋白
  • 货号：
    CSB-MP007402MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Edn3
  • Uniprot No.：
  • 别名：
    Edn3Endothelin-3; ET-3; Preproendothelin-3; PPET3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    97-117
  • 氨基酸序列
    CTCF TYKDKECVYY CHLDIIW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • 基因功能参考文献：
    1. study of the interplay between the EDN3 and beta1-integrin signalling pathways during ENS ontogenesis and the role of EDN3 in enteric neural crest cell adhesion PMID: 27905407
    2. Control of differentiation of mouse enteric nervous system progenitor cells by EDN3 requires regulation of Ednrb expression by SOX10 and ZEB2. PMID: 28063956
    3. Endothelin3 signaling has a critical role in development of UV-induced melanoma in a mouse model PMID: 24992383
    4. colonic migrating motor complexes occur in mice lacking the endothelin-3 gene PMID: 25708159
    5. Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis. PMID: 25487064
    6. changes in spinal afferent innervation and visceral pain transmission from the aganglionic rectum in ls/ls mice with deletions of the endothelin-3 gene PMID: 21320883
    7. EDN3 worked synergistically to induce melanocyte differentiation in vitro PMID: 15768389
    8. a coordinate and balanced interaction between SOX10, endothelin-3 and endothelin B receptor is required for normal enteric nervous system and melanocyte development PMID: 16650841
    9. Using quantitative real-time polymerase chain reaction (PCR) we demonstrated reduced levels of endothelin-3 mRNA in the male mouse bowel at the time that ENS precursors migrate into the colon. PMID: 17131407
    10. an ENU-induced mutation in endothelin 3 results in a mouse model of Waardenburg syndrome type IV PMID: 17516928
    11. Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. PMID: 17611578

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Endothelin/sarafotoxin family
  • 数据库链接：

    KEGG: mmu:13616

    STRING: 10090.ENSMUSP00000029030

    UniGene: Mm.9478