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  4. Recombinant Mouse ETS translocation variant 5 (Etv5)

Recombinant Mouse ETS translocation variant 5 (Etv5)

  • 中文名称：
    小鼠Etv5重组蛋白
  • 货号：
    CSB-YP880439MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Etv5重组蛋白
  • 货号：
    CSB-EP880439MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Etv5重组蛋白
  • 货号：
    CSB-EP880439MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Etv5重组蛋白
  • 货号：
    CSB-BP880439MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Etv5重组蛋白
  • 货号：
    CSB-MP880439MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Etv5
  • Uniprot No.：
  • 别名：
    Etv5ETS translocation variant 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-510
  • 氨基酸序列
    MDGFCDQQVP FMVPGKSRSE DCRGRPLIDR KRKFVDTDLA HDSEELFQDL SQLQEAWLAE AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA KYGEKCLYNY CAYDRKPPSG FKPLTPPATP LSPTHQNSLF PPPQATLPTS GLTPGAGPVQ GVGPAPTPHS LPEPGSQQQT FAVPRPPHQP LQMPKMMPES QYPSEQRFQR QLSEPSHPFP PQSGVPGDSR PSYHRQMSEP IVPAAPPPLQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC ADSEVPNCQS SYMRGGYFSS SHEGFPYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECPLNEEDT LPLTHFEDNP AYLLDMDRCS SLPYTEGFAY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
  • 基因功能参考文献：
    1. CIC-ETV5 axis is critical for regulation of follicular helper T cell development PMID: 28855737
    2. ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis PMID: 29532564
    3. High Etv5 expression is associated with glioma. PMID: 29787563
    4. This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development. PMID: 27909004
    5. Etv5 is expressed alveolar type II cells in adult lung.Etv5 is a critical output of Ras signaling in alveolar type II cells, contributing to both lung homeostasis and tumor initiation. PMID: 28351980
    6. SOX9 regulation of ETV5 contributes to the control of male fertility PMID: 27498191
    7. this study shows that Etv5 plays a crucial role in regulating IL-10 production in Th2 cells by facilitating the binding of IL-10-inducing transcription factors at the Il10 locus PMID: 28100679
    8. findings demonstrate that ETV5 promotes IL-9 production in Th9 cells by binding and recruiting histone acetyltransferases to the Il9 locus at sites distinct from PU.1. data define a role for ETV5 in Th9 development and extend the paradigm of related transcription factors having complementary functions during differentiation PMID: 27496971
    9. substrate that mediates RFWD2 function in lung branching PMID: 27335464
    10. bioinformatic analysis, real-time PCR, and luciferase assay validated that AK015322 serves as a decoy of microRNA-19b-3p (miR-19b-3p), antagonizes its function, and attenuates the repression of its endogenous target transcriptional factor Ets-variant 5 (ETV5) which was a pivotal gene for spermatogonial stem cell self-renewal PMID: 27822884
    11. Further investigations identified Pak1-ERM as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK signaling ensures timely epithelial apoptotic death at postimplantation. PMID: 26184908
    12. The data of this study suggested that the obesity-associated transcription factor ETV5 normally acts to diminish circulating glucocorticoids. PMID: 25813907
    13. ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells. PMID: 26224636
    14. Noise-decreased levels of ROCK2 results in reduction of phosphorylation of ERM that leads to depolymerization of actin filaments PMID: 25683353
    15. The transcription factors Etv5 and STAt3 control TH17 cell development and allergic airway inflammation. PMID: 24486067
    16. A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse. PMID: 24204802
    17. Mouse germline stem (GS) cell transfected with an activated form of Map2k1 have upregulated Etv5 and Bcl6b gene expression. PMID: 22491947
    18. found to be a critical downstream regulator of glial cell line-derived neurotrophic factor-signaling that mediated the expression of several known spermatogonial stem cell self-renewal related genes PMID: 21816850
    19. Results suggest that Etv5 is important for the developmental competence of germ cells and the regulation of responses to steroid hormones in female mice. PMID: 21478265
    20. Data show that miR-21 is regulated by the transcription factor ETV5, known to be critical for SSC self-renewal. PMID: 21768389
    21. Data show for the first time that Sertoli cells are chemoattractive for stem/progenitor spermatogonia, and that production of specific chemokines is regulated by ETV5. PMID: 20799334
    22. This study suggested that the etv5 do not regualte the dopamine pathway in the mouse midbrain. PMID: 20610757
    23. ERM is a transcription factor in the ets family, within which it forms the PEA3 group. PMID: 12871699
    24. expression of Erm is initially restricted to the distal buds of the developing mouse lung PMID: 12941618
    25. ETS-1, PEA3, and ERM have roles in regulation of caveolin-1 transcription in epithelial cells PMID: 15138262
    26. Mice with targeted disruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome PMID: 16107850
    27. Erm is involved in SP-C regulation, which results from an interaction with TTF-1 PMID: 16613858
    28. Results identify common and unique pathways that regulate Etv5 and Gdnf mRNA in Sertoli cells. PMID: 17574550
    29. GDNF up-regulation of Bcl6b, Erm, and Lhx1 expression through Src family kinase signaling is a key component of the intracellular mechanism for spermatogonial stem cells self-renewal. PMID: 17597063
    30. ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer PMID: 17638886
    31. Together, our findings define Erm as an upstream regulator of a transcriptional program selective to subsynaptic nuclei at the NMJ and underscore the importance of transcriptional control of local synaptic protein accumulation. PMID: 17785180
    32. The blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5(-/-) mouse. PMID: 17911411
    33. Etv5(-/-) mice are infertile even when sperm is produced. PMID: 18032421
    34. The results show that Etv4 and Etv5 are expressed in granulosa and cumulus cells during folliculogenesis and ovulation, suggesting that they influence cellular events in the ovary by regulating downstream genes such as Ptgs2. PMID: 18492810
    35. Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3- or Erm-dependent transcription. PMID: 18827017
    36. FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells. PMID: 19301256
    37. results indicate that ETV5 expression begins in fetal Sertoli cells and neonatal gonocytes of the germ cell lineage; loss of ETV5 results in decreased RET expression with possible inhibition of downstream GDNF/RET/GFRA1 signaling PMID: 19369650
    38. FGF activity in the limb is not only responsible for maintaining posterior-specific Shh expression, but it also acts via Etvs to prevent inappropriate anterior expansion of Shh. PMID: 19386268
    39. ETV4 and ETV5 act downstream of FGF signaling to inhibit Shh expression in the anterior limb bud. PMID: 19386269
    40. endogenous Ets factors, including Erm, have tumor-restricting roles in the intestinal epithelium PMID: 19545444
    41. Etv5 is positively regulated by Ret signaling in the ureteric bud tips PMID: 19898483

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    In the brain, expressed predominantly in the cerebral cortex, the amygdala and the hypothalamus. Within the cerebral cortex, there is conspicuously high expression in cortical layers 2, 4 and 6 while expression is almost absent from layers 1, 3 and 5. Hig
  • 数据库链接：

    KEGG: mmu:104156

    STRING: 10090.ENSMUSP00000078551

    UniGene: Mm.155708