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  4. Recombinant Mouse ETS translocation variant 2 (Etv2)

Recombinant Mouse ETS translocation variant 2 (Etv2)

  • 中文名称：
    小鼠Etv2重组蛋白
  • 货号：
    CSB-YP007855MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Etv2重组蛋白
  • 货号：
    CSB-EP007855MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Etv2重组蛋白
  • 货号：
    CSB-EP007855MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Etv2重组蛋白
  • 货号：
    CSB-BP007855MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Etv2重组蛋白
  • 货号：
    CSB-MP007855MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Etv2
  • Uniprot No.：
  • 别名：
    Etv2; Er71; Etsrp71ETS translocation variant 2; Ets-related protein 71
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-335
  • 氨基酸序列
    MDLWNWDEAS LQEVPPGDKL TGLGAEFGFY FPEVALQEDT PITPMNVEGC WKGFPELDWN PALPHEDVPF QAEPVAHPLP WSRDWTDLGC NTSDPWSCAS QTPGPAPPGT SPSPFVGFEG ATGQNPATSA GGVPSWSHPP AAWSTTSWDC SVGPSGATYW DNGLGGEAHE DYKMSWGGSA GSDYTTTWNT GLQDCSIPFE GHQSPAFTTP SKSNKQSDRA TLTRYSKTNH RGPIQLWQFL LELLHDGARS SCIRWTGNSR EFQLCDPKEV ARLWGERKRK PGMNYEKLSR GLRYYYRRDI VLKSGGRKYT YRFGGRVPVL AYQDDMGHLP GAEGQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
  • 基因功能参考文献：
    1. HIF1alpha activation of Etv2 in embryonic stem cells followed by NOTCH1 signaling is required for the generation arterial endothelial cells that are capable of arteriogenesis and revascularization of ischemic tissue. PMID: 28781077
    2. This study aimed to evaluate the effects of the E-twenty six (ETS) factor Ets variant 2 (ETV2) gene expression in angiogenesis and the effect of ETV2 gene therapy in a mouse model of hindlimb ischemia. PMID: 28424975
    3. Foxh1 regulated FLK1+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2. PMID: 28912455
    4. findings demonstrate a critical role for Etv2-miR-130a-Jarid2 in vascular patterning both in vitro and in vivo PMID: 29232705
    5. These findings demonstrate that Etv2 is an important regulator of hematopoietic regeneration. PMID: 28461595
    6. Study discuss the functional significance of ETV2 in embryonic vessel development, postnatal angiogenesis and direct cell reprogramming. [review] PMID: 26694034
    7. Etv2 transactivates miR-130a in the endothelial progenitors. PMID: 26565905
    8. Endothelial ETV2 is required for postnatal vascular repair and regeneration. PMID: 26586661
    9. studies define upstream and downstream networks that serve as a transcriptional rheostat to regulate Etv2 gene expression PMID: 26396195
    10. These findings highlight the critical role that transient ETV2 expression plays in the regulation of hematopoietic and endothelial cell lineage specification and stability. PMID: 25802403
    11. ETV2 directly regulates Sox7, and ETV2 governs endothelial development by regulating transcriptional networks which include Sox7. PMID: 24762086
    12. We show that ER71 directly interacts with OVOL2 and that such interaction is critical for FLK1(+) cell generation and their differentiation into downstream cell lineages. PMID: 25267199
    13. Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation in vasculogenesis. PMID: 24727028
    14. Gata2 functions as a cofactor of Etv2 in the transcriptional regulation of mesodermal progenitors during embryogenesis. PMID: 24583263
    15. study demonstrated using the embryonic stem cell/embryoid body system that Etv2 could rescue the Flk1 mutant phenotype, but Flk1 could not rescue the Etv2 mutant phenotype, further supporting the notion that the Flk1-Etv2 cascade is operational during hemato-endothelial development PMID: 23606617
    16. study to show the critical timeframe of Etv2 requirement and help to know if Etv2 has any function around E9.5 when most endothelial cells(EC) have completed differentiation; also tried to examine if Etv2 expression can define a distinct intermediate step of EC differentiation from Flk-1+/VECAD- mesoderm to VECAD+ differentiated ECs PMID: 23795570
    17. VEGF activates Etv2 by signaling through Flk1, which activates Creb through the p38 MAPK signaling cascade. PMID: 23185546
    18. Studies demonstrate that Etv2 is expressed during and required for yolk sac hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2. PMID: 22628281
    19. ETV2 marks hemogenic endothelium in gastrulating embryos and is absolutely required for the formation of this precursor at the onset of hematopoiesis. PMID: 22733530
    20. Data suggest that Etv2 expression should be tightly regulated to achieve normal vascular development and hematopoiesis. PMID: 22659386
    21. Data establish that ETV2 is required very transiently to specify mesodermal precursors to hematopoiesis and vasculogenesis and that SCL is one of the key downstream targets of ETV2 in controlling hematopoietic specification. PMID: 22570122
    22. Data suggest a mechanism by which SRY induces Sox9 and Er71 transcription early in testis differentiation. PMID: 22613723
    23. ER71-deficient Flk-1(+) mesoderm displayed enhanced Wnt signaling, which was reduced by ER71 re-introduction. PMID: 22343916
    24. Data suggest that Flk-1(+)/PDGFRalpha(+) primitive mesoderm is committed into Flk-1(+)/PDGFRalpha(-) vascular mesoderm through Etv2/ER71. PMID: 21911838
    25. Results identify ER71 as a critical regulator of mesodermal fate decisions that acts to specify the hematopoietic and endothelial lineages at the expense of cardiac lineages. PMID: 21989919
    26. The Er71 is an important regulator of hematopoietic stem cells in adult mice. PMID: 21425416
    27. Etsrp71 gene was cloned and its promoter was characterized. PMID: 15780752
    28. TSGA impairs the ability of ER71 to activate transcription PMID: 16619273
    29. identify human Etv2/ER71 and mouse ER71 proteins as functional orthologs of Ets PMID: 18270322
    30. Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. PMID: 19129488

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    Testis.
  • 数据库链接：

    KEGG: mmu:14008

    STRING: 10090.ENSMUSP00000103782

    UniGene: Mm.4829