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  4. Recombinant Mouse ETS domain-containing protein Elk-3 (Elk3)

Recombinant Mouse ETS domain-containing protein Elk-3 (Elk3)

  • 中文名称：
    小鼠Elk3重组蛋白
  • 货号：
    CSB-YP007606MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Elk3重组蛋白
  • 货号：
    CSB-EP007606MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Elk3重组蛋白
  • 货号：
    CSB-EP007606MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Elk3重组蛋白
  • 货号：
    CSB-BP007606MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Elk3重组蛋白
  • 货号：
    CSB-MP007606MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Elk3; Erp; NetETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-409
  • 氨基酸序列
    MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI SRESLLLQDG DCKVSPEGRE VHRHGLSSLK SASRNEYLHS GLYSSFTINS LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR TVIRFVTNKT DKHITRPVVS LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP SSSRSPSLSP DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP SIHFWSSLSP VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV LLSPSSQKS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
  • 基因功能参考文献：
    1. Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression. PMID: 29269298
    2. Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling. PMID: 27538444
    3. Elk3 has distinct roles in maintaining retinal artery integrity. PMID: 25203538
    4. coexpression of KLF4 led to repression of Elk-3 promoter activity PMID: 25351511
    5. ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density. PMID: 23708702
    6. Elk-3 is a strong repressor of NOS2 promoter activity and mRNA levels, and endogenous expression of Elk-3 inversely correlates with NOS2 PMID: 12896968
    7. A regulator of angiogenesis that can switch to an activator following induction by pro-angiogenic molecules. PMID: 12975317
    8. Net is a negative regulator of PAI-1 expression and is thereby involved in cell migration. PMID: 16314510
    9. Elk-3 serves as an important repressor of heme oxygenase 1 (HO-1) gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of inflammatory stimuli PMID: 16456000
    10. Data show that hypoxia regulates Net differently from the other ternary complex factors and that Net plays a role in the hypoxic response in vivo in mice and in cells. PMID: 17403894
    11. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    Heart, liver, lung, kidney and muscle.
  • 数据库链接：

    KEGG: mmu:13713

    STRING: 10090.ENSMUSP00000008542

    UniGene: Mm.4454