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  4. Recombinant Mouse EGF-like repeat and discoidin I-like domain-containing protein 3 (Edil3)

Recombinant Mouse EGF-like repeat and discoidin I-like domain-containing protein 3 (Edil3)

  • 中文名称：
    小鼠Edil3重组蛋白
  • 货号：
    CSB-YP007399MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Edil3重组蛋白
  • 货号：
    CSB-EP007399MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Edil3重组蛋白
  • 货号：
    CSB-EP007399MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Edil3重组蛋白
  • 货号：
    CSB-BP007399MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Edil3重组蛋白
  • 货号：
    CSB-MP007399MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Edil3
  • Uniprot No.：
  • 别名：
    Edil3; Del1EGF-like repeat and discoidin I-like domain-containing protein 3; Developmentally-regulated endothelial cell locus 1 protein; Integrin-binding protein DEL1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-480
  • 氨基酸序列
    DICNPNP CENGGICLSG LADDSFSCEC PEGFAGPNCS SVVEVASDEE KPTSAGPCIP NPCHNGGTCE ISEAYRGDTF IGYVCKCPRG FNGIHCQHNI NECEAEPCRN GGICTDLVAN YSCECPGEFM GRNCQYKCSG PLGIEGGIIS NQQITASSTH RALFGLQKWY PYYARLNKKG LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP EYIKSYKIAY SNDGKTWAMY KVKGTNEEMV FRGNVDNNTP YANSFTPPIK AQYVRLYPQI CRRHCTLRME LLGCELSGCS EPLGMKSGHI QDYQITASSV FRTLNMDMFT WEPRKARLDK QGKVNAWTSG HNDQSQWLQV DLLVPTKVTG IITQGAKDFG HVQFVGSYKL AYSNDGEHWM VHQDEKQRKD KVFQGNFDND THRKNVIDPP IYARFIRILP WSWYGRITLR SELLGCAEEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
  • 基因功能参考文献：
    1. these results indicate a protective role for Del-1 in postoperative peritoneal adhesion formation. PMID: 29684347
    2. these data reveal an unrecognised function of endogenous Del-1 as a local inhibitor of ischaemia-induced angiogenesis by restraining LFA-1-dependent homing of pro-angiogenic haematopoietic cells to ischaemic tissues PMID: 28447099
    3. Del-1-induced HSC proliferation and myeloid lineage commitment were mediated by beta3 integrin on hematopoietic progenitors. PMID: 28846069
    4. Del-1 intercepted oxLDL before its receptor binding to reduce atherogenesis PMID: 27784857
    5. EDIL3-mediated activation of TGF-beta and ERK signaling could provide therapeutic implications for HCC. PMID: 25980764
    6. Study identified Del-1 as an endogenous homeostatic factor of the CNS protecting from neuroinflammation in the course of CNS autoimmunity PMID: 25385367
    7. Del-1 controls NF-kappaB-activated MIF production in macrophages. PMID: 24504014
    8. The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment. PMID: 24416060
    9. Bleomycin-induced pulmonary fibrosis increased collagen deposition and TGF-beta production in the lung of Del-1(-/-) mice. PMID: 24525119
    10. Decreased Del-1 expression is associated with salivary gland inflammation in Sjogren syndrome. PMID: 24060278
    11. Observed increased leukocyte accumulation, inflammation, and higher apoptosis in the adrenal glands of Del-1-deficient mice. Del-1 deficiency was also associated with reduced corticosterone and ACTH levels 24 hours after lipopolysaccharide administration. PMID: 23364949
    12. Del-1 suppressed LFA-1-dependent recruitment of neutrophils and IL-17-triggered inflammatory pathology and may thus be a promising therapeutic agent for inflammatory diseases. PMID: 22447028
    13. Del-1 plays a physiological role in the clearance of phosphatidylserine-expressing microparticles by endothelium. PMID: 22388320
    14. The apoptosis-inducing activity of Del1 could be mapped to the third EGF motif, which fitted the consensus sequence CX(D/N)XXXX(F/Y)XCXC, wherein the aspartic acid residue (D) could be beta-hydroxylated. PMID: 20171188
    15. mediates vascular smooth muscle cells adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3) PMID: 11959660
    16. acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis PMID: 12074641
    17. Del-1 is expressed in ischemic tissue. Del-1 stimulates angiogenesis, an effect that is dependent on the RGD motif and a second signaling sequence in the discoidin-I-like domain. PMID: 14981004
    18. Demonstration of Del-1 and milk fat globule-EGF-factor 8 (MFG-E8) binding to phosphatidylserine exposed on apoptotic cells suggests the existence of macrophage subsets that use Del-1 or MFG-E8 differently to engulf apoptotic cells. PMID: 15004195
    19. Del1 (Edil3) is induced by a number of growth factors/cytokines including VEGF, indicating the possible involvement of Del1 in tumor angiogenesis. PMID: 15964546
    20. Fusion with the deposition domain of Del1 dramatically alters the distribution of exogenous proteins in mice. PMID: 17701220
    21. Constitutive expression of Del1 in skin does not affect skin vascularity or improve wound healing. PMID: 17764695
    22. Del-1 may participate in modulating cerebral angiogenesis, and that gene transfer of Del-1 may provide a novel and potent means for stimulating cerebral angiogenesis. PMID: 18534562
    23. study describes Del-1 as an anti-adhesive factor that interferes with the integrin LFA-1-dependent leukocyte-endothelial adhesion; Del-1 is an endogenous inhibitor of inflammatory cell recruitment PMID: 19008446

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in angioblasts and early endothelial cells. By embryonic day 13.5, also expressed in a restricted group of non-endothelial cells including chondrocytes and retinal neurons.
  • 数据库链接：

    KEGG: mmu:13612

    STRING: 10090.ENSMUSP00000080462

    UniGene: Mm.125580