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  4. Recombinant Mouse E3 ubiquitin-protein ligase pellino homolog 3 (Peli3)

Recombinant Mouse E3 ubiquitin-protein ligase pellino homolog 3 (Peli3)

  • 货号：
    CSB-YP803958MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803958MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803958MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803958MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803958MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Peli3
  • Uniprot No.：
  • 别名：
    Peli3; E3 ubiquitin-protein ligase pellino homolog 3; Pellino-3; EC 2.3.2.27; RING-type E3 ubiquitin transferase pellino homolog 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-445
  • 氨基酸序列
    MVLEGNPDVG SPRTSDLQHP GSQGSCILSC PGEEALAGEE PIKYGELIVL GYNGCLASGD KGRRRSRLAL SRRPHANGVK PDVMHHISTP LVSKALSNRG QHSISFTLSR SHSVIVEYTH DSDKDMFQIG RSTENMIDFV VTDTSPGGGA TEGPSAQSTI SRYACRILCD RRPPYTARIY AAGFDASSNI FLGERAAKWR TPDGLMDGLT TNGVLVMHPA GGFSEDSAPG VWREISVCGN VYTLRDSRSA QQRGKLVENE SNVLQDGSLI DLCGATLLWR TPAGLLRAPT LKQLEAQRQE ANAARPQCPV GLSTLAFPSP ARGRTAPDKQ QPWVYVRCGH VHGYHGWGCR RERGPQEREC PLCRLVGPYV PLWLGQEAGL CLDPGPPSHA FAPCGHVCSE KTARYWAQTP LPHGTHAFHA ACPFCGAWLT GELGCVRLIF QGPLD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
  • 基因功能参考文献：
    1. Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling. PMID: 26310831
    2. autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B expression PMID: 25483963
    3. Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha. PMID: 24113711
  • 蛋白家族：
    Pellino family
  • 数据库链接：

    KEGG: mmu:240518

    STRING: 10090.ENSMUSP00000025834

    UniGene: Mm.277580