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  4. Recombinant Mouse Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Dyrk2)

Recombinant Mouse Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Dyrk2)

  • 中文名称：
    小鼠Dyrk2重组蛋白
  • 货号：
    CSB-YP729255MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dyrk2重组蛋白
  • 货号：
    CSB-EP729255MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dyrk2重组蛋白
  • 货号：
    CSB-EP729255MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dyrk2重组蛋白
  • 货号：
    CSB-BP729255MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dyrk2重组蛋白
  • 货号：
    CSB-MP729255MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dyrk2
  • Uniprot No.：
  • 别名：
    Dyrk2Dual specificity tyrosine-phosphorylation-regulated kinase 2; EC 2.7.12.1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-599
  • 氨基酸序列
    MLTRKPSAAA PAAYPTGRGG DTAVRQLQAS PGIGAGAPRS GVGTGPPSPI ALPPLRASNA TTTAHTIGGS KHTMNDHLHL NSHGQIQVQQ LFEDNSNKRT VLTTQPNGLT TVGKTGLPGV PERQLESIHR RQGSSTSLKS MEGMGKVKAS PMTPEQAMKQ YMQKLTAFEH HEIFSYPEIY FLGPNAKKRQ GMTGGPNNGG YDDDQGSYVQ VPHDHVAYRY EVLKVIGKGS FGQVVKAYDH KVHQHVALKM VRNEKRFHRQ AAEEIRILEH LRKQDKDNTM NVIHMLENFT FRNHICMTFE LLSMNLYELI KKNKFQGFSL PLVRKFAHSI LQCLDALHKN RIIHCDLKPE NILLKQQGRS SIKVIDFGSS CYEHQRVYTY IQSRFYRAPE VILGARYGMP IDMWSLGCIL AELLTGYPLL PGEDEGDQLA CMIELLGMPS QKLLDASKRA KNFVSSKGYP RYCTVTTLSD GSVVLNGGRS RRGKLRGPPE SREWGNALKG CDDPLFLDFL KQCLEWDPAV RMTPGQALRH PWLRRRLPKP PTGEKTAVKR VTESTGAITS ISKLPPPSSS ASKLRTNLAQ MTDANGNIQQ RTVLPKLVS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX.
  • 基因功能参考文献：
    1. Dyrk2 regulates osteoclast fusion in a cell heterotypic manner. PMID: 28332708
    2. DYRK2 regulates tumor progression through modulation of c-Jun and c-Myc PMID: 22307329
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
  • 数据库链接：

    KEGG: mmu:69181

    STRING: 10090.ENSMUSP00000004281

    UniGene: Mm.45565