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  4. Recombinant Mouse Doublecortin domain-containing protein 2 (Dcdc2)

Recombinant Mouse Doublecortin domain-containing protein 2 (Dcdc2)

  • 中文名称：
    Recombinant Mouse Doublecortin domain-containing protein 2(Dcdc2),Yeast
  • 货号：
    CSB-YP691543MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Doublecortin domain-containing protein 2(Dcdc2),Yeast
  • 货号：
    CSB-EP691543MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Doublecortin domain-containing protein 2(Dcdc2),Yeast
  • 货号：
    CSB-EP691543MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Doublecortin domain-containing protein 2(Dcdc2),Yeast
  • 货号：
    CSB-BP691543MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Doublecortin domain-containing protein 2(Dcdc2),Yeast
  • 货号：
    CSB-MP691543MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dcdc2
  • Uniprot No.：
  • 别名：
    Dcdc2; Dcdc2a; Kiaa1154Doublecortin domain-containing protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-475
  • 氨基酸序列
    MNGPSSRSSH LSQPVVKSVL VYRNGDPFFA GRRVVIHEKK VSSFDVFLKE VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI ESGGNYVAGG PEAFKKLNYL DIGEIKKRPM EAVNTEVKPV IHSRINVSAR FRKSLHEPCT IFLIANGDLI SPASRLLIPK KALNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE LENGQFYVAV GRDKFKRLPY SELLFDKSAM RRPYGQKASS LPPMVGSRKS KGSGNYRQSK STIGSSDNSS PQPLKRKGKK DSNSEKPTKV KQSVKSKTSH QAIPDNGEGI FKAGAERSET RGAAEVQEDE DTQVEVPVDQ RPAEIVDEEE DGEKTSKDAN QKEDFSAMNG ETEDRGGSKA AGTSEQEEGI PDHGEKKSSP SRVNGGTDEE NGEELDQVAE ELQPTEDEKG KAEGDNSGQD EAGLDAQRPP RPEVTVTSPQ ENEENEANKA SSAVA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length.
  • 基因功能参考文献：
    1. Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types. PMID: 25130614
    2. Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (NMDAR) PMID: 24094509
    3. These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin. PMID: 21689730
    4. heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits PMID: 21883923
  • 亚细胞定位：
    Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, kinocilium. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Expressed in hair cells of the inner ear.
  • 数据库链接：

    KEGG: mmu:195208

    STRING: 10090.ENSMUSP00000063650

    UniGene: Mm.284719