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  4. Recombinant Mouse Desmocollin-2 (Dsc2), partial

Recombinant Mouse Desmocollin-2 (Dsc2), partial

  • 中文名称：
    小鼠Dsc2重组蛋白
  • 货号：
    CSB-YP007190MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dsc2重组蛋白
  • 货号：
    CSB-EP007190MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dsc2重组蛋白
  • 货号：
    CSB-EP007190MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dsc2重组蛋白
  • 货号：
    CSB-BP007190MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dsc2重组蛋白
  • 货号：
    CSB-MP007190MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dsc2
  • Uniprot No.：
  • 别名：
    Dsc2; Dsc3; Desmocollin-2; Epithelial type 2 desmocollin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  • 基因功能参考文献：
    1. Downregulation of DSC2 is associated with arrhythmogenic cardiomyopathy. PMID: 27834139
    2. Cardiac specific overexpression of desmocollin-2 induces necrosis, acute inflammation and patchy cardiac fibrotic remodeling leading to fulminant biventricular cardiomyopathy. PMID: 28339476
    3. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling. PMID: 24166502
    4. plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1) differentially regulates the proximal promoters of Dsc2 and Dsc3 PMID: 23652796
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 组织特异性：
    In all epithelia tested and heart.
  • 数据库链接：

    KEGG: mmu:13506

    STRING: 10090.ENSMUSP00000042905

    UniGene: Mm.280547