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  4. Recombinant Mouse Dermatopontin (Dpt)

Recombinant Mouse Dermatopontin (Dpt)

  • 中文名称：
    小鼠Dpt重组蛋白
  • 货号：
    CSB-YP007156MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dpt重组蛋白
  • 货号：
    CSB-EP007156MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dpt重组蛋白
  • 货号：
    CSB-EP007156MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dpt重组蛋白
  • 货号：
    CSB-BP007156MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dpt重组蛋白
  • 货号：
    CSB-MP007156MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dpt
  • Uniprot No.：
  • 别名：
    Dpt; Dermatopontin; Early quiescence protein 1; EQ-1; Tyrosine-rich acidic matrix protein; TRAMP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-201
  • 氨基酸序列
    QY GGYGYPYQQY QDYGDDGWVN LNRQGFSYQC PHGQVVVAVR SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM EWYQKCSNNG LVAGFQSRYF ESVLDREWQF YCCRYSKRCP YSCWMTTEYP SHYGEDMDMI SYDYDFYMRG ATTTFSAVER DRQWKFIMCR MTDYDCEFEN V
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.
  • 基因功能参考文献：
    1. These data suggest that DPT fosters adherence but is not required for steady-state hematopoiesis in vivo. PMID: 28844660
    2. These findings illustrate a previously uncharacterized role of Dpt in maintaining hematopoietic stem cells ex vivo. PMID: 27365423
    3. DPT may affect testicular function by affecting the integrity of the bloodtestis barrier. PMID: 26861869
    4. The DP-4 peptide activated Fn and enhanced cell adhesion activity PMID: 25092262
    5. The present study provides the first evidence that DPT may be a novel effector of cadmium chloride, highlighting the significant role of DPT in the regulation of claudin-11 expression PMID: 24909373
    6. Aging in the mdx diaphragm seems to be associated with a drastic increase in extracellular matrix proteins incliding dermatopontin. PMID: 22614334
    7. Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis PMID: 12230512
    8. Cloning of early quiescence-1 gene: Identification of a role in cell quiescence. PMID: 14980498
    9. Dermatopontin is an abundant protein in demineralized bone matrix, and it can inhibit the stimulatory effects of BMP-2 on ALP activity in C2C12 cells. PMID: 17118749
    10. results suggest that, at the time of implantation, dermatopontin expression in the uterus is primarily regulated spatio-temporally by progesterone via progesterone receptors, and is modulated by the decidual response during implantation PMID: 17202853

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Dermatopontin family
  • 数据库链接：

    KEGG: mmu:56429

    STRING: 10090.ENSMUSP00000027861

    UniGene: Mm.28935