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  4. Recombinant Mouse Decaprenyl-diphosphate synthase subunit 2 (Pdss2)

Recombinant Mouse Decaprenyl-diphosphate synthase subunit 2 (Pdss2)

  • 中文名称：
    小鼠Pdss2重组蛋白
  • 货号：
    CSB-YP654258MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pdss2重组蛋白
  • 货号：
    CSB-EP654258MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pdss2重组蛋白
  • 货号：
    CSB-EP654258MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pdss2重组蛋白
  • 货号：
    CSB-BP654258MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pdss2重组蛋白
  • 货号：
    CSB-MP654258MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pdss2
  • Uniprot No.：
  • 别名：
    Pdss2; Dlp1; Decaprenyl-diphosphate synthase subunit 2; EC 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 2; Decaprenyl pyrophosphate synthase subunit 2; Solanesyl-diphosphate synthase subunit 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-401
  • 氨基酸序列
    MSLRQLLLRL SGYLGASGPP SRHWWYFRSL DSISSAGSWR GRSSRSPAHW NQVVSEAEKI VGYPASFMSL RCLLSDELSN IAMQVRKLVG TGHPLLTTAR ALVHDSRHNL QLRGLVVLLI SKAAGPSTRN AACQNYDMVS GVYSCQRSLA EITELIHTAL LVHRGIVNLS ELQSSDGPLK DMQFGNKIAI LSGDFLLANA CNGLALLQNT KVVELLSSAL MDLVHGVYQE NSASTKENSI PDDIGISTWK EQTFLSHCAL LAKSCQAAME LAKHDAAVQD MAFQYGKHMA MSHKINADLQ PFIKDKASDS KTFNLNSAPV VLHQEFLGRD LWIKQIGEAQ EKGSLNYSKL RETIKAGKGV TSAIDLCRYH GNKALEALES FPPSEARSAL ENIVFAVTRF S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. May play a role during cerebellar development. May regulate mitochondrial respiratory chain function.
  • 基因功能参考文献：
    1. kidney-specific loss of mitochondria triggered by oxidative stress may be the cause of renal failure in Pdss2(kd/kd) mice PMID: 23150520
    2. During cerebellum development, Pdss2 knockout results in severe cerebellum hypoplasia by impairing cell migration and eliciting ectopic apoptosis, whereas Pdss2 knockout in Purkinje cells at postnatal stages leads to the development of cerebellar ataxia. PMID: 21871565
    3. The s report that homozygousPdss2 missense mutants also demonstrate significant neuromuscular deficits, as validated by behavioral and coordination assays. PMID: 21983691
    4. Data show that focal segmental glomerulopathy-like kidney disease in Pdss2 mutant animals with primary coenzyme Q (CoQ) deficiency is significantly ameliorated by oral treatment with probucol. PMID: 21567994
    5. Calorie restriction increased both ubiquinone homologues and mPDSS2 mRNA in skeletal muscle, but mCOQ7 was decreased. PMID: 21447381
    6. kd is mutant allele of novel gene for prenyltransferase-like mitochondrial protein (PLMP). Alternatively spliced. Larger gene product has one domain resembling transprenyltransferase and another similar to geranylgeranyl pyrophosphate synthase. (PLMP) PMID: 15200409
    7. murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (mDLP1). PMID: 16262699
    8. In kd/kd mice the tubular epithelial defect triggers autoimmune interstitial nephritis, whereas a defect in podocytes leads to proteinuria and glomerulosclerosis. PMID: 16282678
    9. a presumed autoimmune kidney disease in mice with the missense Pdss2(kd/kd) genotype can be attributed to a mitochondrial CoQ biosynthetic defect PMID: 18437205
    10. Dietary supplementation with coenzyme Q10 provides a dramatic rescue of both proteinuria and interstitial nephritis in the Pdss2kd/kd mutant mice. PMID: 18784258

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    FPP/GGPP synthase family
  • 数据库链接：

    KEGG: mmu:71365

    STRING: 10090.ENSMUSP00000093393

    UniGene: Mm.490430