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  4. Recombinant Mouse Dachshund homolog 2 (Dach2)

Recombinant Mouse Dachshund homolog 2 (Dach2)

  • 中文名称：
    Recombinant Mouse Dachshund homolog 2(Dach2),Yeast
  • 货号：
    CSB-YP838790MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 2(Dach2),Yeast
  • 货号：
    CSB-EP838790MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 2(Dach2),Yeast
  • 货号：
    CSB-EP838790MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 2(Dach2),Yeast
  • 货号：
    CSB-BP838790MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Dachshund homolog 2(Dach2),Yeast
  • 货号：
    CSB-MP838790MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dach2
  • Uniprot No.：
  • 别名：
    Dach2Dachshund homolog 2; Dach2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-634
  • 氨基酸序列
    MAVSAPPVIS ATSSSAGVPG GLFRAEPLYS SPGEPPRLTP NMINSFMANN HNGSVLGGGI GGGSGGSSNT NTNECRMVDM HGVKVASFLM DGQELICLPQ VFDLFLKHLV GGLHTVYTKL KRLDISPVVC TVEQVRILRG LGAIQPGVNR CKLITRKDFE TLFTDCTNAR RKRQMTRKQA VNSSRPGRPP KRSLGVLQDN ARLLPHAVPG LLSPGLITPT GITAAAMAEA MKLQKMKLMA MNTLQGNGSQ NGTESEPDDL NSTTGGSESS WDKDKIQSPL AASGPQHGIA HAALAGQPGL GGAPTLNPLQ QNHLLSNRLD LPFMMMPHPL LPVSLPPASV AMAMNQMNHL NTIANMAAAA QIHSPLSRAG ASVIKERIPE SPSPAPSLEE SHRPGSQTSS HPSSSVSSSP SQMDHHSERM VMMPNNREEL IVDQDNGQSI KKFQRDNKEE VPAQIPVMKS PLDKIQLAPG QALHPGFPGP FIFADSLSSV ETLLTNIQGL LKVALDNARI QEKQIQQEKK ELRIELFRER EIRENLERQL AVELQSRSTM QKRLKKEKKA KRKLQEALEF ESKRREQVEQ ALKQATSGDS GLRMLKDSGI PDIEIENSGT PHDSAAMQGG NYYCLAMAQQ LCSA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain.
  • 基因功能参考文献：
    1. Unlike Drosophila dachshund mutants that lack eyes and exhibit leg truncations, the eyes and limbs of Dach double mutants are present, suggesting differences between Dach and dachshund gene function during embryonic eye and limb formation. PMID: 16470613
    2. a HDAC-Dach2-myogenin signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle PMID: 17075071
    3. HDAC4 is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin, and nAChR PMID: 17873280
    4. With Dach1, may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct. PMID: 18395837
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DACH/dachshund family
  • 组织特异性：
    Expressed in embryo, and at lower levels in the newborn.
  • 数据库链接：

    KEGG: mmu:93837

    STRING: 10090.ENSMUSP00000064393

    UniGene: Mm.79760