Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse DNA damage-inducible transcript 4-like protein (Ddit4l)

Recombinant Mouse DNA damage-inducible transcript 4-like protein (Ddit4l)

  • 中文名称：
    Recombinant Mouse DNA damage-inducible transcript 4-like protein(Ddit4l),Yeast
  • 货号：
    CSB-YP855359MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse DNA damage-inducible transcript 4-like protein(Ddit4l),Yeast
  • 货号：
    CSB-EP855359MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse DNA damage-inducible transcript 4-like protein(Ddit4l),Yeast
  • 货号：
    CSB-EP855359MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse DNA damage-inducible transcript 4-like protein(Ddit4l),Yeast
  • 货号：
    CSB-BP855359MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse DNA damage-inducible transcript 4-like protein(Ddit4l),Yeast
  • 货号：
    CSB-MP855359MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ddit4l
  • Uniprot No.：
  • 别名：
    Ddit4l; Rtp801l; Smhs1DNA damage-inducible transcript 4-like protein; HIF-1 responsive protein RTP801-like; Soleus muscle atrophied after hindlimb suspension protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-193
  • 氨基酸序列
    MVATGSLSSK NPASISELLD GGYHPGSLLS DFDYWDYVVP EPNLNEVVFE ETTCQNLVKM LENCLSRSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP CGLRGCVMHV NLEIENVCKK LDRIVCDASV VPTFELTLVF KQESCPWTSL KDFFFSRGRF SSGLKRTLIL SSGFRLVKKK LYSLIGTTVI EEC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
  • 基因功能参考文献：
    1. Data showed that DDiT4L may be an important transducer of pathological stress to autophagy through mTOR signaling in the heart. PMID: 28246202
    2. Axonal injury-induced upregulation of the stress-responsive REDD2 leads to mTOR inhibition triggering early dendritic arbor retraction, neuronal dysfunction and subsequent death of adult retinal neurons. PMID: 25257176
    3. IRF-1 physically interacts with REDD2 in the large cytoplasmic protein complex PMID: 24412152
    4. SMHS1 was found to be expressed in skeletal muscle, and comparisons of its expression in atrophied versus hypertrophied muscles and in oxidative versus glycolytic muscles suggested that SMHS1 contributes to muscle energy metabolism phenotypes. PMID: 15607738
    5. RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions PMID: 15632201
    6. REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch. PMID: 19129461

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    DDIT4 family
  • 数据库链接：

    KEGG: mmu:73284

    STRING: 10090.ENSMUSP00000058896

    UniGene: Mm.250841