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  4. Recombinant Mouse DNA-binding protein SATB1 (Satb1)

Recombinant Mouse DNA-binding protein SATB1 (Satb1)

  • 中文名称：
    小鼠Satb1重组蛋白
  • 货号：
    CSB-YP713882MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Satb1重组蛋白
  • 货号：
    CSB-EP713882MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Satb1重组蛋白
  • 货号：
    CSB-EP713882MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Satb1重组蛋白
  • 货号：
    CSB-BP713882MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Satb1重组蛋白
  • 货号：
    CSB-MP713882MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Satb1
  • Uniprot No.：
  • 别名：
    Satb1; DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-764
  • 氨基酸序列
    MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGG KMQGVPLKHS GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY SHSSAAQAKG LIQVGKWNPV PLSYVTDAPD ATVADMLQDV YHVVTLKIQL HSCPKLEDLP PEQWSHTTVR NALKDLLKDM NQSSLAKECP LSQSMISSIV NSTYYANVSA AKCQEFGRWY KHFKKTKDMM VEMDSLSELS QQGANHVNFG QQPVPGNTAE QPPSPAQLSH GSQPSVRTPL PNLHPGLVST PISPQLVNQQ LVMAQLLNQQ YAVNRLLAQQ SLNQQYLNHP PPVSRSMNKP LEQQVSTNTE VSSEIYQWVR DELKRAGISQ AVFARVAFNR TQGLLSEILR KEEDPKTASQ SLLVNLRAMQ NFLQLPEAER DRIYQDERER SLNAASAMGP APLLSTPPSR PPQVKTATLA TERNGKPENN TMNINASIYD EIQQEMKRAK VSQALFAKVA ATKSQGWLCE LLRWKEDPSP ENRTLWENLS MIRRFLSLPQ PERDAIYEQE SNAVHHHGDR PPHIIHVPAE QIQQQQQQQQ QQQQQQQPPP PPPQPQPQPQ AGPRLPPRQP TVASSAESDE ENRQKTRPRT KISVEALGIL QSFIQDVGLY PDEEAIQTLS AQLDLPKYTI IKFFQNQRYY LKHHGKLKDN SGLEVDVAEY KDEELLKDLE ESVQDKNANT LFSVKLEEEL SVEGSTDVNA DLKD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1.
  • 基因功能参考文献：
    1. SATB1 is essential for maintaining TCR responsiveness during the induction and effector phases and may provide a novel therapeutic target for T cell-mediated autoimmune diseases. PMID: 29388727
    2. Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein to upregulate miR-223 expression in chronic kidney disease-mineral and bone disorder PMID: 29442043
    3. SATB1 shapes the primary T cell pool by directing lineage-specific transcriptional programs in the thymus. PMID: 28494867
    4. SATB1cKO mice, in which the SATB1 gene is specifically deleted from hematopoietic cells, develop Sjogren syndrome by 4 wk of age, soon after weaning. PMID: 29127143
    5. these results identify a role for Satb1 in the lineage choice between pluripotency and differentiation and further our understanding of early embryonic lineage segregation. PMID: 28289135
    6. This study demonstrating that Satb1-dependent Cntn5 expression in ON-OFF direction-selective ganglion cells leads to branch-specific homophilic interactions with interneurons. PMID: 28781169
    7. we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development PMID: 27454343
    8. this study shows that Satb1-dependent Treg cell-specific super-enhancers activation is crucial for Treg cell lineage specification in the thymus PMID: 27992401
    9. Tumor-driven, unremitting expression of Satb1 in activated Zbtb46+ inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 and IL-6. PMID: 26876172
    10. These results suggest that SATB1 plays an essential role in establishment of immune tolerance. PMID: 26667169
    11. Fluorosed mouse ameloblasts have increased SATB1 retention and Galphaq activity. PMID: 25090413
    12. The results indicated that the expression of SATB1 in both mRNA and protein levels was significantly decreased after cells transferred with siRNA sequence for 48 h, the proliferation of MF9 cells was significantly inhibited. PMID: 25596087
    13. SATB1 is indispensable for lymphocyte differentiation and stem cell development. (Review) PMID: 24938377
    14. The ubiquitin-like domain-CUT repeat-like tandem of SATB1 are required for DNA binding. PMID: 25124042
    15. governs lymphoid lineage specification PMID: 23791645
    16. Satb1 is a regulator that promotes hematopoietic stem cells quiescence and represses lineage commitment. PMID: 23563689
    17. SATB1 as a critical regulator of interneuron maturation and terminal differentiation in the mammalian cortex. PMID: 23142661
    18. These data suggest that Satb1 is required for medial ganglionic eminence-derived interneuron differentiation, connectivity, and survival. PMID: 23223290
    19. The Satb1 proteins are dispensable for X chromosome inactivation in mice. PMID: 23079603
    20. Satb1 is expressed throughout the central nervous system including midbrain dopaminergic neurons, but not in cholinergic or serotonergic neurons or glial cells. PMID: 21658419
    21. In the cerebral cortex, Satb1 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc, and Bdnf) and other key neuronal genes, many of which have been implicated in synaptic plasticity. PMID: 22064485
    22. These data provide a novel mechanism by which Satb1, a direct downstream target of p63, contributes in epidermal morphogenesis via establishing tissue-specific chromatin organization and gene expression in epidermal progenitor cells. PMID: 21930775
    23. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. PMID: 21841785
    24. hypothalamic expression of CREB-binding protein (CBP) and CBP-binding partner Special AT-rich sequence binding protein 1 (SATB-1) is highly correlated with lifespan across five strains of mice PMID: 19924292
    25. in thymocyte nuclei, SATB1 has a cage-like 'network' distribution circumscribing heterochromatin and selectively tethers specialized DNA sequences onto its network PMID: 12692553
    26. essential role for SATB1 late in the development and maturation of CD8SP T cells PMID: 15814699
    27. SATB1-mediated transcriptional repression is regulated by nuclear matrix binding PMID: 15851481
    28. SATB1 is a necessary determinant for transcriptionally active chromatin structure that forms on T(H)2 cell activation. PMID: 17057718
    29. A requirement in CD8 coreceptor reversal identifies SATB1 as an essential trans-regulator of CD8 lineage fate, whose action may be mediated via recruitment to the E8(III) double positive enhancer. PMID: 18722016
    30. SATB1 is a crucial silencing factor contributing to the initiation of X inactivation. PMID: 19386260
    31. Satb1 and Satb2 bind the Nanog locus in vivo and the balance of Satb1 and Satb2 contributes to the plasticity of Nanog expression and ES cell pluripotency PMID: 19933152

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  • 亚细胞定位：
    Nucleus. Nucleus, PML body.
  • 蛋白家族：
    CUT homeobox family
  • 组织特异性：
    Expressed in the subventricular zone, rostral migratory stream and in the olfactory bulb (at protein level). Mainly expressed in thymus, spleen, and lymph nodes with a lower level observed in the brain.
  • 数据库链接：

    KEGG: mmu:20230

    STRING: 10090.ENSMUSP00000116006

    UniGene: Mm.311655