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  4. Recombinant Mouse Cysteine and histidine-rich domain-containing protein 1 (Chordc1)

Recombinant Mouse Cysteine and histidine-rich domain-containing protein 1 (Chordc1)

  • 中文名称：
    Recombinant Mouse Cysteine and histidine-rich domain-containing protein 1(Chordc1),Yeast
  • 货号：
    CSB-YP866664MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and histidine-rich domain-containing protein 1(Chordc1),Yeast
  • 货号：
    CSB-EP866664MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and histidine-rich domain-containing protein 1(Chordc1),Yeast
  • 货号：
    CSB-EP866664MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and histidine-rich domain-containing protein 1(Chordc1),Yeast
  • 货号：
    CSB-BP866664MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cysteine and histidine-rich domain-containing protein 1(Chordc1),Yeast
  • 货号：
    CSB-MP866664MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Chordc1
  • Uniprot No.：
  • 别名：
    Chordc1; Chp1; Morgana; Cysteine and histidine-rich domain-containing protein 1; CHORD domain-containing protein 1; CHORD-containing protein 1; Chp-1; Protein morgana
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-331
  • 氨基酸序列
    ALLCYNRGC GQRFDPEANS DDACTYHPGV PVFHDALKGW SCCKRRTTDF SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELSELKP KFQEHIIQAP KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGSE EDKKEEDSDE IKIGTSCKNG GCSKTYQGLQ SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS DFNTFLAQEG CTRGKHVWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS LPELSQVEAN STLLNVHIVF EGEKEFHQNV KLWGVIDVKR SYVTMTATKI EITMRKAEPM QWASLELPTT KKQEKQKDIA D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling. Involved in stress response. Prevents tumorigenesis.
  • 基因功能参考文献：
    1. Morgana silencing blocks metastasis formation in breast cancer mouse models and this phenotype is reverted by IkappaBalpha downregulation. PMID: 29158506
    2. Loss of Morgana expression is associated with drug resistance and chronic myeloid leukemia. PMID: 25678499
    3. morgana causes PTEN destabilization, by inhibiting ROCK activity PMID: 24615293
    4. Overexpression of morgana/CHP-1 in NIH3T3 cells leads to the increased stress resistance of the cells. PMID: 20493909
    5. Morgana/chp-1 downregulation promotes the interaction between ROCK II and nucleophosmin, leading to an increased ROCK II kinase activity, which results in centrosome amplification. PMID: 20230755
    6. Full length sequence, gene structure and expression of Chp-1. PMID: 12965203
    7. The first biochemical evidence demonstrating that mammalian Chp-1 is a novel Hsp90-interacting protein. PMID: 15642353
    8. results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain. PMID: 17253150

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  • 组织特异性：
    Ubiquitously expressed. Highly expressed in spleen, lung and brain (at protein level). Expressed in proliferating myoblasts and its expression remained steady after. Its expression undergoes diurnal and circadian changes in hypothalamus. Highly expressed
  • 数据库链接：

    KEGG: mmu:66917

    STRING: 10090.ENSMUSP00000001825

    UniGene: Mm.103534